Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer
Objective: Serum 25-hydroxyvitamin D (25(OH)D) deficiency has been known to be associated with the risk and mortality of several cancers. However, the role of 25(OH)D in papillary thyroid cancer (PTC) remains controversial. This study aimed to investigate the association between 25(OH)D and clinicop...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2023-12-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/13/1/EC-23-0373.xml |
| _version_ | 1827584565724577792 |
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| author | Yuting Shao Xiaole Hu Yuxi Wang Yi Shao Luchuan Li Qingdong Zeng Hong Lai Lei Sheng |
| author_facet | Yuting Shao Xiaole Hu Yuxi Wang Yi Shao Luchuan Li Qingdong Zeng Hong Lai Lei Sheng |
| author_sort | Yuting Shao |
| collection | DOAJ |
| description | Objective: Serum 25-hydroxyvitamin D (25(OH)D) deficiency has been known to be associated with the risk and mortality of several cancers. However, the role of 25(OH)D in papillary thyroid cancer (PTC) remains controversial. This study aimed to investigate the association between 25(OH)D and clinicopathologic features of PTC.
Methods: Patients who underwent thyroidectomy were retrospectively reviewed. Serum 25(OH)D levels were measured within a week prior to surgery. The patients were categorized into four quartiles according to season-specific 25(OH)D levels. The association between 25(OH)D levels and clinicopathologic features of PTC was analyzed.
Results: A total of 2932 patients were enrolled in the study. The 25(OH)D levels were significantly higher in patients with lymph node metastasis (LNM; P < 0.001), lateral LNM (P < 0.001), and multifocal tumors (P < 0.001). Compared to the first quartile (Q1) of 25(OH)D level, the third quartile (Q3) and the fourth quartile (Q4) showed an unadjusted OR of 1.36 (95% CI: 1.09–1.69; P = 0.006) and 1.76 (95% CI: 1.42–2.19; P < 0.001) for LNM (P for trend < 0.001), respectively. An increased risk of multifocal tumors was strongly associated with high 25(OH)D concentration (P for trend <0.001). Similar results were obtained after adjusting for confounding factors.
Conclusion: High 25(OH)D levels are associated with aggressive features of PTC, such as lymph node metastasis and multifocality. |
| first_indexed | 2024-03-08T23:33:11Z |
| format | Article |
| id | doaj.art-d17253b144124158af95429772952dcc |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-03-08T23:33:11Z |
| publishDate | 2023-12-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-d17253b144124158af95429772952dcc2023-12-14T10:38:41ZengBioscientificaEndocrine Connections2049-36142023-12-0113118https://doi.org/10.1530/EC-23-0373Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancerYuting Shao0Xiaole Hu1Yuxi Wang2Yi Shao3Luchuan Li4Qingdong Zeng5Hong Lai6Lei Sheng7Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Operating Room, Qilu Hospital of Shandong University, Shandong, ChinaDepartment of Breast and Thyroid Surgery, People’s Hospital of Mengyin County, Linyi, Shandong, ChinaDepartment of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaObjective: Serum 25-hydroxyvitamin D (25(OH)D) deficiency has been known to be associated with the risk and mortality of several cancers. However, the role of 25(OH)D in papillary thyroid cancer (PTC) remains controversial. This study aimed to investigate the association between 25(OH)D and clinicopathologic features of PTC. Methods: Patients who underwent thyroidectomy were retrospectively reviewed. Serum 25(OH)D levels were measured within a week prior to surgery. The patients were categorized into four quartiles according to season-specific 25(OH)D levels. The association between 25(OH)D levels and clinicopathologic features of PTC was analyzed. Results: A total of 2932 patients were enrolled in the study. The 25(OH)D levels were significantly higher in patients with lymph node metastasis (LNM; P < 0.001), lateral LNM (P < 0.001), and multifocal tumors (P < 0.001). Compared to the first quartile (Q1) of 25(OH)D level, the third quartile (Q3) and the fourth quartile (Q4) showed an unadjusted OR of 1.36 (95% CI: 1.09–1.69; P = 0.006) and 1.76 (95% CI: 1.42–2.19; P < 0.001) for LNM (P for trend < 0.001), respectively. An increased risk of multifocal tumors was strongly associated with high 25(OH)D concentration (P for trend <0.001). Similar results were obtained after adjusting for confounding factors. Conclusion: High 25(OH)D levels are associated with aggressive features of PTC, such as lymph node metastasis and multifocality.https://ec.bioscientifica.com/view/journals/ec/13/1/EC-23-0373.xml25-hydroxyvitamin dpapillary thyroid canceraggressivenesslymph node metastasismultifocality |
| spellingShingle | Yuting Shao Xiaole Hu Yuxi Wang Yi Shao Luchuan Li Qingdong Zeng Hong Lai Lei Sheng Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer Endocrine Connections 25-hydroxyvitamin d papillary thyroid cancer aggressiveness lymph node metastasis multifocality |
| title | Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer |
| title_full | Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer |
| title_fullStr | Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer |
| title_full_unstemmed | Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer |
| title_short | Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer |
| title_sort | association of serum 25 hydroxyvitamin d levels with aggressiveness of papillary thyroid cancer |
| topic | 25-hydroxyvitamin d papillary thyroid cancer aggressiveness lymph node metastasis multifocality |
| url | https://ec.bioscientifica.com/view/journals/ec/13/1/EC-23-0373.xml |
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