Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort study
Pubertal development may be altered in boys with cryptorchidism and hypospadias, but existing knowledge is inconsistent. Therefore, we investigated the association between cryptorchidism and hypospadias and pubertal development in a large cohort study. Boys in the Puberty Cohort, a cohort nested wit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=6;spage=551;epage=556;aulast=Arendt |
| _version_ | 1818275667905609728 |
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| author | Linn Håkonsen Arendt Andreas Ernst Lea Lykke Braskhøj Lauridsen Nis Brix Jørn Olsen Cecilia Høst Ramlau-Hansen |
| author_facet | Linn Håkonsen Arendt Andreas Ernst Lea Lykke Braskhøj Lauridsen Nis Brix Jørn Olsen Cecilia Høst Ramlau-Hansen |
| author_sort | Linn Håkonsen Arendt |
| collection | DOAJ |
| description | Pubertal development may be altered in boys with cryptorchidism and hypospadias, but existing knowledge is inconsistent. Therefore, we investigated the association between cryptorchidism and hypospadias and pubertal development in a large cohort study. Boys in the Puberty Cohort, a cohort nested within the Danish National Birth Cohort, were included in this study. Information on cryptorchidism and hypospadias was retrieved from the Danish National Patient Register. From 11 years until 18 years or full pubertal development, information on physical markers of pubertal development was provided biannually, including Tanner stages, axillary hair, acne, voice break, and first ejaculation. In multivariate regression models for interval censored data, the mean (95% confidence intervals [CIs]) differences in months in obtaining the pubertal markers between boys with and without the anomalies were estimated. Among 7698 boys, 196 (2.5%) had cryptorchidism and 60 (0.8%) had hypospadias. Boys with hypospadias experienced first ejaculation and voice break 7.7 (95% CI: 2.5–13.0) months and 4.5 (95% CI: 0.3–8.7) months later than boys without hypospadias. The age at attaining the Tanner stages for gonadal and pubic hair growth was also higher, though not statistically significant. Pubertal development seemed unaffected in boys with mild as well as severe cryptorchidism. In conclusion, hypospadias may be associated with delayed pubertal development, but pubertal development seems unaffected by cryptorchidism. The relation between hypospadias and later pubertal development may be due to the underlying shared in utero risk or genetic factors. |
| first_indexed | 2024-12-12T22:33:24Z |
| format | Article |
| id | doaj.art-d1732c1ec37f487b9be3acfb7d3dbab8 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-12T22:33:24Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-d1732c1ec37f487b9be3acfb7d3dbab82022-12-22T00:09:33ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622019-01-0121655155610.4103/aja.aja_3_19Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort studyLinn Håkonsen ArendtAndreas ErnstLea Lykke Braskhøj LauridsenNis BrixJørn OlsenCecilia Høst Ramlau-HansenPubertal development may be altered in boys with cryptorchidism and hypospadias, but existing knowledge is inconsistent. Therefore, we investigated the association between cryptorchidism and hypospadias and pubertal development in a large cohort study. Boys in the Puberty Cohort, a cohort nested within the Danish National Birth Cohort, were included in this study. Information on cryptorchidism and hypospadias was retrieved from the Danish National Patient Register. From 11 years until 18 years or full pubertal development, information on physical markers of pubertal development was provided biannually, including Tanner stages, axillary hair, acne, voice break, and first ejaculation. In multivariate regression models for interval censored data, the mean (95% confidence intervals [CIs]) differences in months in obtaining the pubertal markers between boys with and without the anomalies were estimated. Among 7698 boys, 196 (2.5%) had cryptorchidism and 60 (0.8%) had hypospadias. Boys with hypospadias experienced first ejaculation and voice break 7.7 (95% CI: 2.5–13.0) months and 4.5 (95% CI: 0.3–8.7) months later than boys without hypospadias. The age at attaining the Tanner stages for gonadal and pubic hair growth was also higher, though not statistically significant. Pubertal development seemed unaffected in boys with mild as well as severe cryptorchidism. In conclusion, hypospadias may be associated with delayed pubertal development, but pubertal development seems unaffected by cryptorchidism. The relation between hypospadias and later pubertal development may be due to the underlying shared in utero risk or genetic factors.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=6;spage=551;epage=556;aulast=Arendtcongenital abnormalities; cryptorchidism; hypospadias; prenatal exposure delayed effects; puberty; tanner stages |
| spellingShingle | Linn Håkonsen Arendt Andreas Ernst Lea Lykke Braskhøj Lauridsen Nis Brix Jørn Olsen Cecilia Høst Ramlau-Hansen Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort study Asian Journal of Andrology congenital abnormalities; cryptorchidism; hypospadias; prenatal exposure delayed effects; puberty; tanner stages |
| title | Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort study |
| title_full | Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort study |
| title_fullStr | Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort study |
| title_full_unstemmed | Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort study |
| title_short | Timing of pubertal development in boys born with cryptorchidism and hypospadias: a nationwide cohort study |
| title_sort | timing of pubertal development in boys born with cryptorchidism and hypospadias a nationwide cohort study |
| topic | congenital abnormalities; cryptorchidism; hypospadias; prenatal exposure delayed effects; puberty; tanner stages |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=6;spage=551;epage=556;aulast=Arendt |
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