Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom State
Introduction: CD4 count is a reliable prognostic indicator of immune response to anti retroviral therapy. This study seeks to determine the proportion of HAART naive patients that achieved an early immunologic response at six months of commencing HAART and to predict factors of early immunological...
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| Format: | Article |
| Language: | English |
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Nigerian Medical Association, Akwa Ibom State Branch
2021-10-01
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| Series: | Ibom Medical Journal |
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| Online Access: | https://ibommedicaljournal.org/index.php/imjhome/article/view/38 |
| _version_ | 1797271905657421824 |
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| author | Ekanem AM Udofia EA Ekrikpo UE Opara D Johnson O Ndifon W Onajole A |
| author_facet | Ekanem AM Udofia EA Ekrikpo UE Opara D Johnson O Ndifon W Onajole A |
| author_sort | Ekanem AM |
| collection | DOAJ |
| description |
Introduction: CD4 count is a reliable prognostic indicator of immune response to anti retroviral therapy. This study seeks to determine the proportion of HAART naive patients that achieved an early immunologic response at six months of commencing HAART and to predict factors of early immunological response to HAART.
Materials and Methods: This was an observational longitudinal study among 287 consecutively recruited HAART naive patients in 11 HIV treatment centres of Akwa Ibom using a semi-structured interviewer administered questionnaire for data collection. Data analysis was done using Stata statistical software at a level of significance of P<0.05.
Results: About 75% respondents achieved an early immune response. Multivariate analysis revealed that being female (OR 2.47, P=0.001) predicted achievement of early immunological response while being civil servants/professionals (OR 0.44, P =0.02), unemployed (OR 0.34, P= 0.04) and every 10 cell increase in CD4 cell count at baseline (OR 0.94, P=0.001) predicted non achievement of early immunological response.
Conclusion: The majority of HAART naïve patients commenced on anti-retroviral therapy achieved an early immunological response at 6 months on ART. Operating flexible HIV services that covers morning, afternoon, evening and weekend services and male friendly HIV services may improve civil servants and males’ utilization of HIV care and support services. Job creation for the unemployed is also recommended.
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| first_indexed | 2024-03-07T14:16:53Z |
| format | Article |
| id | doaj.art-d17346fbbb7d4c39844217eb8c8e7df4 |
| institution | Directory Open Access Journal |
| issn | 1597-7188 2735-9964 |
| language | English |
| last_indexed | 2024-03-07T14:16:53Z |
| publishDate | 2021-10-01 |
| publisher | Nigerian Medical Association, Akwa Ibom State Branch |
| record_format | Article |
| series | Ibom Medical Journal |
| spelling | doaj.art-d17346fbbb7d4c39844217eb8c8e7df42024-03-06T12:03:13ZengNigerian Medical Association, Akwa Ibom State BranchIbom Medical Journal1597-71882735-99642021-10-0114410.61386/imj.v14i4.38Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom StateEkanem AM0Udofia EAEkrikpo UEOpara DJohnson ONdifon WOnajole ADepartment of Community Health, University of Uyo, Uyo, Akwa Ibom State, Nigeria Introduction: CD4 count is a reliable prognostic indicator of immune response to anti retroviral therapy. This study seeks to determine the proportion of HAART naive patients that achieved an early immunologic response at six months of commencing HAART and to predict factors of early immunological response to HAART. Materials and Methods: This was an observational longitudinal study among 287 consecutively recruited HAART naive patients in 11 HIV treatment centres of Akwa Ibom using a semi-structured interviewer administered questionnaire for data collection. Data analysis was done using Stata statistical software at a level of significance of P<0.05. Results: About 75% respondents achieved an early immune response. Multivariate analysis revealed that being female (OR 2.47, P=0.001) predicted achievement of early immunological response while being civil servants/professionals (OR 0.44, P =0.02), unemployed (OR 0.34, P= 0.04) and every 10 cell increase in CD4 cell count at baseline (OR 0.94, P=0.001) predicted non achievement of early immunological response. Conclusion: The majority of HAART naïve patients commenced on anti-retroviral therapy achieved an early immunological response at 6 months on ART. Operating flexible HIV services that covers morning, afternoon, evening and weekend services and male friendly HIV services may improve civil servants and males’ utilization of HIV care and support services. Job creation for the unemployed is also recommended. https://ibommedicaljournal.org/index.php/imjhome/article/view/38Early Immune ResponseHAART NaïveAkwa Ibom |
| spellingShingle | Ekanem AM Udofia EA Ekrikpo UE Opara D Johnson O Ndifon W Onajole A Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom State Ibom Medical Journal Early Immune Response HAART Naïve Akwa Ibom |
| title | Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom State |
| title_full | Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom State |
| title_fullStr | Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom State |
| title_full_unstemmed | Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom State |
| title_short | Predictors of early immunologic response among highly active anti-retroviral therapy naïve patients in Akwa Ibom State |
| title_sort | predictors of early immunologic response among highly active anti retroviral therapy naive patients in akwa ibom state |
| topic | Early Immune Response HAART Naïve Akwa Ibom |
| url | https://ibommedicaljournal.org/index.php/imjhome/article/view/38 |
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