Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice

Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice

Abstract Background Carbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With respect to genotoxicity, carbendazim is deemed to be non-mutagenic in vitro, but it causes indicative DNA damage in vivo and chromosome aber...

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Main Authors: Takako Iso, Kenichiro Suzuki, Yasumasa Murata, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genes and Environment
Subjects:
Carbendazim
In vivo mutagenicity
Transgenic rodent gene mutation assay
Online Access:https://doi.org/10.1186/s41021-024-00299-4

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