Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report
Abstract Background Intrathoracic Solitary Fibrous Tumors (SFT) mainly arise from the pleura; however, these tumors may also originate from the mediastinum. We present a rare case of posterior SFT extending to several mediastinal sites and with an unusual large size, successfully treated with surgic...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-023-02366-3 |
| _version_ | 1797451570564038656 |
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| author | Parviz Mardani Mohammad Nekooeian Saba Zangeneh Hooman Kamran Reza Shahriarirad Mohammad Hossein Anbardar Armin Amirian Masoud Vafabin |
| author_facet | Parviz Mardani Mohammad Nekooeian Saba Zangeneh Hooman Kamran Reza Shahriarirad Mohammad Hossein Anbardar Armin Amirian Masoud Vafabin |
| author_sort | Parviz Mardani |
| collection | DOAJ |
| description | Abstract Background Intrathoracic Solitary Fibrous Tumors (SFT) mainly arise from the pleura; however, these tumors may also originate from the mediastinum. We present a rare case of posterior SFT extending to several mediastinal sites and with an unusual large size, successfully treated with surgical resection. Case presentation A 66-year-old female presented with an initial manifestation of ambiguous pain in the chest and dysphagia and later developed pitting edema in both lower extremities and cachexia five months before admission. Chest imaging confirmed a mediastinal mass (17 × 15 × 8 cm) which was surgically removed. Immunohistochemistry confirmed the diagnosis of a solitary fibrous tumor with positive B-cell lymphoma 2, STAT6, and CD99, negative S100 and smooth muscle actin, and low levels of Ki67 (5–7%). The patient’s follow-up course was unremarkable. Conclusion Mediastinal SFTs may grow extremely huge, with the potential to invade multiple adjacent sites. Surgical removal of the tumor remains the mainstay of treatment in these cases. |
| first_indexed | 2024-03-09T14:56:32Z |
| format | Article |
| id | doaj.art-d174b7355c8041f7b117d5c7fabf44a8 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-03-09T14:56:32Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-d174b7355c8041f7b117d5c7fabf44a82023-11-26T14:12:15ZengBMCJournal of Cardiothoracic Surgery1749-80902023-09-011811610.1186/s13019-023-02366-3Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case reportParviz Mardani0Mohammad Nekooeian1Saba Zangeneh2Hooman Kamran3Reza Shahriarirad4Mohammad Hossein Anbardar5Armin Amirian6Masoud Vafabin7Thoracic and Vascular Surgery Research Center, Shiraz University of Medical SciencesSchool of Medicine, Shiraz University of Medical SciencesSchool of Medicine, Fasa University of Medical SciencesThoracic and Vascular Surgery Research Center, Shiraz University of Medical SciencesThoracic and Vascular Surgery Research Center, Shiraz University of Medical SciencesDepartment of Pathology, School of Medicine, Namazee Teaching Hospital, Shiraz University of Medical SciencesThoracic and Vascular Surgery Research Center, Shiraz University of Medical SciencesThoracic and Vascular Surgery Research Center, Shiraz University of Medical SciencesAbstract Background Intrathoracic Solitary Fibrous Tumors (SFT) mainly arise from the pleura; however, these tumors may also originate from the mediastinum. We present a rare case of posterior SFT extending to several mediastinal sites and with an unusual large size, successfully treated with surgical resection. Case presentation A 66-year-old female presented with an initial manifestation of ambiguous pain in the chest and dysphagia and later developed pitting edema in both lower extremities and cachexia five months before admission. Chest imaging confirmed a mediastinal mass (17 × 15 × 8 cm) which was surgically removed. Immunohistochemistry confirmed the diagnosis of a solitary fibrous tumor with positive B-cell lymphoma 2, STAT6, and CD99, negative S100 and smooth muscle actin, and low levels of Ki67 (5–7%). The patient’s follow-up course was unremarkable. Conclusion Mediastinal SFTs may grow extremely huge, with the potential to invade multiple adjacent sites. Surgical removal of the tumor remains the mainstay of treatment in these cases.https://doi.org/10.1186/s13019-023-02366-3Solitary fibrous tumorsMediastinal neoplasmsSurgery |
| spellingShingle | Parviz Mardani Mohammad Nekooeian Saba Zangeneh Hooman Kamran Reza Shahriarirad Mohammad Hossein Anbardar Armin Amirian Masoud Vafabin Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report Journal of Cardiothoracic Surgery Solitary fibrous tumors Mediastinal neoplasms Surgery |
| title | Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report |
| title_full | Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report |
| title_fullStr | Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report |
| title_full_unstemmed | Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report |
| title_short | Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report |
| title_sort | surgical removal of an unusual huge solitary fibrous tumor in the mediastinum a case report |
| topic | Solitary fibrous tumors Mediastinal neoplasms Surgery |
| url | https://doi.org/10.1186/s13019-023-02366-3 |
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