Sodium Alginate—Natural Microencapsulation Material of Polymeric Microparticles
From the multitude of materials currently available on the market that can be used in the development of microparticles, sodium alginate has become one of the most studied natural anionic polymers that can be included in controlled-release pharmaceutical systems alongside other polymers due to its l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/20/12108 |
| _version_ | 1797472861710974976 |
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| author | Olimpia Daniela Frent Laura Gratiela Vicas Narcis Duteanu Claudia Mona Morgovan Tunde Jurca Annamaria Pallag Mariana Eugenia Muresan Sanda Monica Filip Roxana-Liana Lucaciu Eleonora Marian |
| author_facet | Olimpia Daniela Frent Laura Gratiela Vicas Narcis Duteanu Claudia Mona Morgovan Tunde Jurca Annamaria Pallag Mariana Eugenia Muresan Sanda Monica Filip Roxana-Liana Lucaciu Eleonora Marian |
| author_sort | Olimpia Daniela Frent |
| collection | DOAJ |
| description | From the multitude of materials currently available on the market that can be used in the development of microparticles, sodium alginate has become one of the most studied natural anionic polymers that can be included in controlled-release pharmaceutical systems alongside other polymers due to its low cost, low toxicity, biocompatibility, biodegradability and gelatinous die-forming capacity in the presence of Ca<sup>2+</sup> ions. In this review, we have shown that through coacervation, the particulate systems for the dispensing of drugs consisting of natural polymers are nontoxic, allowing the repeated administration of medicinal substances and the protection of better the medicinal substances from degradation, which can increase the capture capacity of the drug and extend its release from the pharmaceutical form. |
| first_indexed | 2024-03-09T20:07:09Z |
| format | Article |
| id | doaj.art-d1755803dda84c49b8755466db93e8da |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:07:09Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d1755803dda84c49b8755466db93e8da2023-11-24T00:28:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201210810.3390/ijms232012108Sodium Alginate—Natural Microencapsulation Material of Polymeric MicroparticlesOlimpia Daniela Frent0Laura Gratiela Vicas1Narcis Duteanu2Claudia Mona Morgovan3Tunde Jurca4Annamaria Pallag5Mariana Eugenia Muresan6Sanda Monica Filip7Roxana-Liana Lucaciu8Eleonora Marian9Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Jiga Street, 410028 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Jiga Street, 410028 Oradea, RomaniaFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timisoara, 2 Square Victoriei, 300006 Timisoara, RomaniaDepartment of Chemistry, Faculty of Informatics and Sciences, University of Oradea, 1 University Street, 410087 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Jiga Street, 410028 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Jiga Street, 410028 Oradea, RomaniaDepartment of Preclinical Discipline, Faculty of Medicine and Pharmacy, 1st December Square 10, University of Oradea, 410087 Oradea, RomaniaDepartment of Physics, Faculty of Informatics and Sciences, University of Oradea, 1 University Street, 410087 Oradea, RomaniaDepartment of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, RomaniaDoctoral School of Biomedical Science, University of Oradea, 1 University Street, 410087 Oradea, RomaniaFrom the multitude of materials currently available on the market that can be used in the development of microparticles, sodium alginate has become one of the most studied natural anionic polymers that can be included in controlled-release pharmaceutical systems alongside other polymers due to its low cost, low toxicity, biocompatibility, biodegradability and gelatinous die-forming capacity in the presence of Ca<sup>2+</sup> ions. In this review, we have shown that through coacervation, the particulate systems for the dispensing of drugs consisting of natural polymers are nontoxic, allowing the repeated administration of medicinal substances and the protection of better the medicinal substances from degradation, which can increase the capture capacity of the drug and extend its release from the pharmaceutical form.https://www.mdpi.com/1422-0067/23/20/12108sodium alginatemicroencapsulationmicroparticlesnatural polysaccharide |
| spellingShingle | Olimpia Daniela Frent Laura Gratiela Vicas Narcis Duteanu Claudia Mona Morgovan Tunde Jurca Annamaria Pallag Mariana Eugenia Muresan Sanda Monica Filip Roxana-Liana Lucaciu Eleonora Marian Sodium Alginate—Natural Microencapsulation Material of Polymeric Microparticles International Journal of Molecular Sciences sodium alginate microencapsulation microparticles natural polysaccharide |
| title | Sodium Alginate—Natural Microencapsulation Material of Polymeric Microparticles |
| title_full | Sodium Alginate—Natural Microencapsulation Material of Polymeric Microparticles |
| title_fullStr | Sodium Alginate—Natural Microencapsulation Material of Polymeric Microparticles |
| title_full_unstemmed | Sodium Alginate—Natural Microencapsulation Material of Polymeric Microparticles |
| title_short | Sodium Alginate—Natural Microencapsulation Material of Polymeric Microparticles |
| title_sort | sodium alginate natural microencapsulation material of polymeric microparticles |
| topic | sodium alginate microencapsulation microparticles natural polysaccharide |
| url | https://www.mdpi.com/1422-0067/23/20/12108 |
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