Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion
Immune reconstitution syndrome is a recognized complication with initiation of highly active antiretroviral therapy for acquired immune deficiency syndrome patients co-infected with hepatitis B. Hepatitis B flares are seen in 20%-25% of patients after initiation of highly active antiretroviral thera...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119303266 |
| _version_ | 1831666386523389952 |
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| author | Michael W. Rowley Amitkumar Patel Wendi Zhou Mark Wong Anil B. Seetharam |
| author_facet | Michael W. Rowley Amitkumar Patel Wendi Zhou Mark Wong Anil B. Seetharam |
| author_sort | Michael W. Rowley |
| collection | DOAJ |
| description | Immune reconstitution syndrome is a recognized complication with initiation of highly active antiretroviral therapy for acquired immune deficiency syndrome patients co-infected with hepatitis B. Hepatitis B flares are seen in 20%-25% of patients after initiation of highly active antiretroviral therapy, an estimated 1%-5% of whom develop clinical hepatitis. We present a case of highly active antiretroviral therapy initiation for HIV that led to a flare of HBV activity despite antiviral therapy directed towards both. Liver biopsy and longitudinal serologic evaluation lend support to the hypothesis that the flare in activity was representative of IRIS. Importantly, we document eAg/eAb seroconversion with the IRIS phenomenon. |
| first_indexed | 2024-12-19T19:51:53Z |
| format | Article |
| id | doaj.art-d176fd23282b430a920263e2201cecf5 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-19T19:51:53Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-d176fd23282b430a920263e2201cecf52022-12-21T20:07:57ZengElsevierAnnals of Hepatology1665-26812019-01-01181220224Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen SeroconversionMichael W. Rowley0Amitkumar Patel1Wendi Zhou2Mark Wong3Anil B. Seetharam4Department of Internal Medicine, Banner University Medical Center Phoenix, Phoenix, AZ, USA; Transplant and Advanced Liver Disease Center, Banner University Medical Center Phoenix, Phoenix, AZ, USA; Correspondence and reprint request:Department of Gastroenterology, Banner University Medical Center Phoenix, Phoenix, AZ, USA; Transplant and Advanced Liver Disease Center, Banner University Medical Center Phoenix, Phoenix, AZ, USADepartment of Pathology, Banner University Medical Center Phoenix, Phoenix, AZ, USA; University of Arizona College of Medicine Phoenix, Phoenix, AZ, USATransplant and Advanced Liver Disease Center, Banner University Medical Center Phoenix, Phoenix, AZ, USA; University of Arizona College of Medicine Phoenix, Phoenix, AZ, USATransplant and Advanced Liver Disease Center, Banner University Medical Center Phoenix, Phoenix, AZ, USA; University of Arizona College of Medicine Phoenix, Phoenix, AZ, USAImmune reconstitution syndrome is a recognized complication with initiation of highly active antiretroviral therapy for acquired immune deficiency syndrome patients co-infected with hepatitis B. Hepatitis B flares are seen in 20%-25% of patients after initiation of highly active antiretroviral therapy, an estimated 1%-5% of whom develop clinical hepatitis. We present a case of highly active antiretroviral therapy initiation for HIV that led to a flare of HBV activity despite antiviral therapy directed towards both. Liver biopsy and longitudinal serologic evaluation lend support to the hypothesis that the flare in activity was representative of IRIS. Importantly, we document eAg/eAb seroconversion with the IRIS phenomenon.http://www.sciencedirect.com/science/article/pii/S1665268119303266Acquired Immune Deficiency SyndromeAIDSHepatitis BHuman Immunodeficiency Virus |
| spellingShingle | Michael W. Rowley Amitkumar Patel Wendi Zhou Mark Wong Anil B. Seetharam Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion Annals of Hepatology Acquired Immune Deficiency Syndrome AIDS Hepatitis B Human Immunodeficiency Virus |
| title | Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion |
| title_full | Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion |
| title_fullStr | Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion |
| title_full_unstemmed | Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion |
| title_short | Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion |
| title_sort | immune reconstitution syndrome with initiation of treatment of hbv hiv co infection activity flare associated with e antigen seroconversion |
| topic | Acquired Immune Deficiency Syndrome AIDS Hepatitis B Human Immunodeficiency Virus |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119303266 |
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