Topologically Organized Networks in the Claustrum Reflect Functional Modularization
Using genetic strategies and viral-based directional tracers, we investigated the topological location and output networks of claustrum (CLA) neuron populations projecting to either the retrosplenial cortex, primary motor cortex, or basolateral amygdala. We found that all three CLA neuron population...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2022.901807/full |
| _version_ | 1818251856986505216 |
|---|---|
| author | Gao Xiang Ham George J. Augustine |
| author_facet | Gao Xiang Ham George J. Augustine |
| author_sort | Gao Xiang Ham |
| collection | DOAJ |
| description | Using genetic strategies and viral-based directional tracers, we investigated the topological location and output networks of claustrum (CLA) neuron populations projecting to either the retrosplenial cortex, primary motor cortex, or basolateral amygdala. We found that all three CLA neuron populations clearly reside in distinct topological locations within the CLA complex and project broadly to multiple downstream targets. Each neuron population projects to different targets, suggesting that each CLA subzone coordinates a unique set of brain-wide functions. Our findings establish that the claustrum complex encompasses at least three minimally overlapping networks that are compartmentalized into different topological subzones. Such modularity is likely to be important for CLA function. |
| first_indexed | 2024-12-12T16:14:56Z |
| format | Article |
| id | doaj.art-d17702a6746d4893b74ba325e2759b8e |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-12T16:14:56Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-d17702a6746d4893b74ba325e2759b8e2022-12-22T00:19:07ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292022-06-011610.3389/fnana.2022.901807901807Topologically Organized Networks in the Claustrum Reflect Functional ModularizationGao Xiang HamGeorge J. AugustineUsing genetic strategies and viral-based directional tracers, we investigated the topological location and output networks of claustrum (CLA) neuron populations projecting to either the retrosplenial cortex, primary motor cortex, or basolateral amygdala. We found that all three CLA neuron populations clearly reside in distinct topological locations within the CLA complex and project broadly to multiple downstream targets. Each neuron population projects to different targets, suggesting that each CLA subzone coordinates a unique set of brain-wide functions. Our findings establish that the claustrum complex encompasses at least three minimally overlapping networks that are compartmentalized into different topological subzones. Such modularity is likely to be important for CLA function.https://www.frontiersin.org/articles/10.3389/fnana.2022.901807/fullclaustrumnetworksconnectivityfunctional modulesclaustrum topologyconnectome |
| spellingShingle | Gao Xiang Ham George J. Augustine Topologically Organized Networks in the Claustrum Reflect Functional Modularization Frontiers in Neuroanatomy claustrum networks connectivity functional modules claustrum topology connectome |
| title | Topologically Organized Networks in the Claustrum Reflect Functional Modularization |
| title_full | Topologically Organized Networks in the Claustrum Reflect Functional Modularization |
| title_fullStr | Topologically Organized Networks in the Claustrum Reflect Functional Modularization |
| title_full_unstemmed | Topologically Organized Networks in the Claustrum Reflect Functional Modularization |
| title_short | Topologically Organized Networks in the Claustrum Reflect Functional Modularization |
| title_sort | topologically organized networks in the claustrum reflect functional modularization |
| topic | claustrum networks connectivity functional modules claustrum topology connectome |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2022.901807/full |
| work_keys_str_mv | AT gaoxiangham topologicallyorganizednetworksintheclaustrumreflectfunctionalmodularization AT georgejaugustine topologicallyorganizednetworksintheclaustrumreflectfunctionalmodularization |