NSABP B-04 trial 25 years later: lessons for oncologists
This critical analysis of the article of B. Fisher et al. “Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation” (2002) was written for physicians interested in learning how evidence based oncology has challenge...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-09-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/648 |
| _version_ | 1797876033761837056 |
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| author | A. Ya. Kim L. I. Markushin S. A. Volchenkov V. K. Osetnik P. I. Sorokin O. G. Matorina A. A. Gavrilyukova V. V. Gushchin |
| author_facet | A. Ya. Kim L. I. Markushin S. A. Volchenkov V. K. Osetnik P. I. Sorokin O. G. Matorina A. A. Gavrilyukova V. V. Gushchin |
| author_sort | A. Ya. Kim |
| collection | DOAJ |
| description | This critical analysis of the article of B. Fisher et al. “Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation” (2002) was written for physicians interested in learning how evidence based oncology has challenged the Halstedian model of breast cancer progression and the radical loco-regional treatment as the way to stop this progression. The 25-year update of the NSABP B-04 study is unique in its design and the remarkable length of follow-up. Our detailed analysis of the article provides an example how oncologists learn about biology of the disease, test the hypothesis of the metastatic spread of the tumor, and what the bases of the modern principles of loco-regional treatment of breast cancer are. Also, the modern clinical recommendations are written using similar systematic analysis of the available literature. The presented analysis explains the logic behind using various end-points. This analysis illustrates how the study helps to dismantle the stereotype that super radical surgical treatment of breast cancer was effective and to promote research in less aggressive loco-regional treatments of other tumors. To our knowledge this type of analysis has never been published before in Russian oncology literature. |
| first_indexed | 2024-04-10T01:55:50Z |
| format | Article |
| id | doaj.art-d178877468c44df388d35516163c7c74 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:55:50Z |
| publishDate | 2019-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-d178877468c44df388d35516163c7c742023-03-13T08:44:37ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272019-09-01152525610.17650/1994-4098-2019-15-2-52-56612NSABP B-04 trial 25 years later: lessons for oncologistsA. Ya. Kim0L. I. Markushin1S. A. Volchenkov2V. K. Osetnik3P. I. Sorokin4O. G. Matorina5A. A. Gavrilyukova6V. V. Gushchin7ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; Высшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-ПетербургВысшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-Петербург; Академия постдипломного образования ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России»ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; Высшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-ПетербургФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; Высшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-ПетербургФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; Высшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-ПетербургФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; Высшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-ПетербургВысшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-Петербург; Академия постдипломного образования ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России»Высшая школа онкологии, Фонд профилактики рака «Не напрасно», Санкт-Петербург; Клиника MercyThis critical analysis of the article of B. Fisher et al. “Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation” (2002) was written for physicians interested in learning how evidence based oncology has challenged the Halstedian model of breast cancer progression and the radical loco-regional treatment as the way to stop this progression. The 25-year update of the NSABP B-04 study is unique in its design and the remarkable length of follow-up. Our detailed analysis of the article provides an example how oncologists learn about biology of the disease, test the hypothesis of the metastatic spread of the tumor, and what the bases of the modern principles of loco-regional treatment of breast cancer are. Also, the modern clinical recommendations are written using similar systematic analysis of the available literature. The presented analysis explains the logic behind using various end-points. This analysis illustrates how the study helps to dismantle the stereotype that super radical surgical treatment of breast cancer was effective and to promote research in less aggressive loco-regional treatments of other tumors. To our knowledge this type of analysis has never been published before in Russian oncology literature.https://ojrs.abvpress.ru/ojrs/article/view/648рак молочной железымастэктомияхолстедфишерnsabp b-04 |
| spellingShingle | A. Ya. Kim L. I. Markushin S. A. Volchenkov V. K. Osetnik P. I. Sorokin O. G. Matorina A. A. Gavrilyukova V. V. Gushchin NSABP B-04 trial 25 years later: lessons for oncologists Опухоли женской репродуктивной системы рак молочной железы мастэктомия холстед фишер nsabp b-04 |
| title | NSABP B-04 trial 25 years later: lessons for oncologists |
| title_full | NSABP B-04 trial 25 years later: lessons for oncologists |
| title_fullStr | NSABP B-04 trial 25 years later: lessons for oncologists |
| title_full_unstemmed | NSABP B-04 trial 25 years later: lessons for oncologists |
| title_short | NSABP B-04 trial 25 years later: lessons for oncologists |
| title_sort | nsabp b 04 trial 25 years later lessons for oncologists |
| topic | рак молочной железы мастэктомия холстед фишер nsabp b-04 |
| url | https://ojrs.abvpress.ru/ojrs/article/view/648 |
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