Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors

Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors

Abstract Searching for targets that allow pharmacological inhibition of cell proliferation in over-proliferative states, such as cancer, leads us to finely understand the complex mechanisms orchestrating the perfect control of mitosis number, frequency and pace as well as the molecular arrangements...

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Bibliographic Details
Main Authors: Wagner Ricardo Montor, Andrei Ronaldo Oliveira Silva Escartin Salas, Fabiana Henriques Machado de Melo
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
Receptor tyrosine kinases
tyrosine kinase inhibitors
MAPK signaling pathways
RAS-mutations
BRAF driven cancers
PI3K/AKT transduction network
Online Access:http://link.springer.com/article/10.1186/s12943-018-0792-2

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http://link.springer.com/article/10.1186/s12943-018-0792-2

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