Toxicity Induced by Cytokines, Glucose, and Lipids Increase Apoptosis and Hamper Insulin Secretion in the 1.1E7 Beta Cell-Line

Toxicity Induced by Cytokines, Glucose, and Lipids Increase Apoptosis and Hamper Insulin Secretion in the 1.1E7 Beta Cell-Line

Basic research on types 1 and 2 diabetes mellitus require early stage studies using beta cells or cell lines, ideally of human origin and with preserved insulin secretion in response to glucose. The 1.1E7 cells are a hybrid cell line resulting from the electrofusion of dispersed human islets and PAN...

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Bibliographic Details
Main Authors: Antonia Diaz-Ganete, Aranzazu Quiroga-de-Castro, Rosa M. Mateos, Francisco Medina, Carmen Segundo, Alfonso M. Lechuga-Sancho
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
beta cell
cytokines
cytotoxicity
diabetes
glucotoxicity
Online Access:https://www.mdpi.com/1422-0067/22/5/2559

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