Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department.
Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted disease, but there is limited data on its epidemiology among urban populations. The urban Emergency Department (ED) is a potential venue for surveillance as it predominantly serves an inner city minority population. We evaluate the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4103852?pdf=render |
| _version_ | 1818858762220339200 |
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| author | Eshan U Patel Melanie A Frank Yu-Hsiang Hsieh Richard E Rothman Amy E O Baker Chadd K Kraus Judy Shahan Charlotte A Gaydos Gabor D Kelen Thomas C Quinn Oliver Laeyendecker |
| author_facet | Eshan U Patel Melanie A Frank Yu-Hsiang Hsieh Richard E Rothman Amy E O Baker Chadd K Kraus Judy Shahan Charlotte A Gaydos Gabor D Kelen Thomas C Quinn Oliver Laeyendecker |
| author_sort | Eshan U Patel |
| collection | DOAJ |
| description | Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted disease, but there is limited data on its epidemiology among urban populations. The urban Emergency Department (ED) is a potential venue for surveillance as it predominantly serves an inner city minority population. We evaluate the seroprevalence and factors associated with HSV-2 infection among patients attending the Johns Hopkins Hospital Adult Emergency Department (JHH ED).An identity unlinked-serosurvey was conducted between 6/2007 and 9/2007 in the JHH ED; sera were tested by the Focus HerpeSelect ELISA. Prevalence risk ratios (PRR) were used to determine factors associated with HSV-2 infection.Of 3,408 serum samples, 1,853 (54.4%) were seropositive for HSV-2. Females (adjPRR = 1.47, 95% CI 1.38-1.56), non-Hispanic blacks (adjPRR = 2.03, 95% CI 1.82-2.27), single (adjPRR = 1.15, 95% CI 1.07-1.25), divorced (adjPRR = 1.28, 95% CI 1.15-1.41), and unemployed patients (adjPRR = 1.13, 95% CI 1.05-1.21) had significantly higher rates of HSV-2 infection. Though certain zip codes had significantly higher seroprevalence of HSV-2, this effect was completely attenuated when controlling for age and gender.Seroprevalence of HSV-2 in the JHH ED was higher than U.S. national estimates; however, factors associated with HSV-2 infection were similar. The high seroprevalence of HSV-2 in this urban ED highlights the need for targeted testing and treatment. Cross-sectional serosurveys in the urban ED may help to examine the epidemiology of HSV-2. |
| first_indexed | 2024-12-19T09:01:26Z |
| format | Article |
| id | doaj.art-d17a185159324569bcb6ed22727fec86 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T09:01:26Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d17a185159324569bcb6ed22727fec862022-12-21T20:28:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10242210.1371/journal.pone.0102422Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department.Eshan U PatelMelanie A FrankYu-Hsiang HsiehRichard E RothmanAmy E O BakerChadd K KrausJudy ShahanCharlotte A GaydosGabor D KelenThomas C QuinnOliver LaeyendeckerHerpes simplex virus type 2 (HSV-2) is a common sexually transmitted disease, but there is limited data on its epidemiology among urban populations. The urban Emergency Department (ED) is a potential venue for surveillance as it predominantly serves an inner city minority population. We evaluate the seroprevalence and factors associated with HSV-2 infection among patients attending the Johns Hopkins Hospital Adult Emergency Department (JHH ED).An identity unlinked-serosurvey was conducted between 6/2007 and 9/2007 in the JHH ED; sera were tested by the Focus HerpeSelect ELISA. Prevalence risk ratios (PRR) were used to determine factors associated with HSV-2 infection.Of 3,408 serum samples, 1,853 (54.4%) were seropositive for HSV-2. Females (adjPRR = 1.47, 95% CI 1.38-1.56), non-Hispanic blacks (adjPRR = 2.03, 95% CI 1.82-2.27), single (adjPRR = 1.15, 95% CI 1.07-1.25), divorced (adjPRR = 1.28, 95% CI 1.15-1.41), and unemployed patients (adjPRR = 1.13, 95% CI 1.05-1.21) had significantly higher rates of HSV-2 infection. Though certain zip codes had significantly higher seroprevalence of HSV-2, this effect was completely attenuated when controlling for age and gender.Seroprevalence of HSV-2 in the JHH ED was higher than U.S. national estimates; however, factors associated with HSV-2 infection were similar. The high seroprevalence of HSV-2 in this urban ED highlights the need for targeted testing and treatment. Cross-sectional serosurveys in the urban ED may help to examine the epidemiology of HSV-2.http://europepmc.org/articles/PMC4103852?pdf=render |
| spellingShingle | Eshan U Patel Melanie A Frank Yu-Hsiang Hsieh Richard E Rothman Amy E O Baker Chadd K Kraus Judy Shahan Charlotte A Gaydos Gabor D Kelen Thomas C Quinn Oliver Laeyendecker Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department. PLoS ONE |
| title | Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department. |
| title_full | Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department. |
| title_fullStr | Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department. |
| title_full_unstemmed | Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department. |
| title_short | Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department. |
| title_sort | prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a baltimore city emergency department |
| url | http://europepmc.org/articles/PMC4103852?pdf=render |
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