Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms

Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms

Background: Pancreatic adenocarcinoma (PAAD) has a considerably bad prognosis, and its pathophysiologic mechanism remains unclear. Thus, we aimed to identify real hub genes to better explore the pathophysiology of PAAD and construct a prognostic panel to better predict the prognosis of PAAD using th...

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Bibliographic Details
Main Authors: Qihang Yuan, Jie Ren, Zhizhou Wang, Li Ji, Dawei Deng, Dong Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Genetics
Subjects:
pancreatic adenocarcinoma
weighted gene co-expression network analysis
hub gene
least absolute shrinkage and selection operator
prognostic signature
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.692953/full

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