Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults
Abstract Background Metabolic flexibility is the ability of skeletal muscle to adapt fuel utilization to the demand for fuel sources [carbohydrates (CHO) and fats (FAT)]. The purpose of this study was to explore muscle energy metabolism and metabolic flexibility under various conditions in sarcopeni...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.12932 |
| _version_ | 1797203392964067328 |
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| author | Marni E. Shoemaker Suzette L. Pereira Vikkie A. Mustad Zachary M. Gillen Brianna D. McKay Jose M. Lopez‐Pedrosa Ricardo Rueda Joel T. Cramer |
| author_facet | Marni E. Shoemaker Suzette L. Pereira Vikkie A. Mustad Zachary M. Gillen Brianna D. McKay Jose M. Lopez‐Pedrosa Ricardo Rueda Joel T. Cramer |
| author_sort | Marni E. Shoemaker |
| collection | DOAJ |
| description | Abstract Background Metabolic flexibility is the ability of skeletal muscle to adapt fuel utilization to the demand for fuel sources [carbohydrates (CHO) and fats (FAT)]. The purpose of this study was to explore muscle energy metabolism and metabolic flexibility under various conditions in sarcopenic (S) versus nonsarcopenic (NS) older adults. Methods Twenty‐two older adults aged 65 years or older were categorized as NS [n = 11; mean ± standard deviation (SD); age = 73.5 ± 6.0 years (males, n = 5; females, n = 6)] or S [n = 11; 81.2 ± 10.5 years (males, n = 6; females, n = 5) based on handgrip strength, body composition and physical performance. Indirect calorimetry was recorded before and after consumption of a high‐CHO meal and during aerobic and anaerobic exercise. Respiratory quotient (RQ), CHO and FAT oxidation were assessed. Venous blood samples were collected for glucose and insulin concentrations. Results At rest, compared with NS, S exhibited a 5–8% higher RQ at 0 (0.72 vs. 0.76) and 120 (0.77 vs. 0.82), 150 (0.76 vs. 0.80), and 180 min (0.74 vs. 0.80) (P = 0.002–0.025); 59–195% higher CHO oxidation at 0, 120, and 180 min (0.0004–0.002 vs. 0.001–0.002 g·min−1·kg‐1) (P = 0.010–0.047); and 20–31% lower FAT oxidation at 0, 15, and 90–180 min (0.0009–0.0022 vs. 0.0011–0.002 g·min−1·kg−1) (P = 0.004–0.038). Glucose levels were significantly elevated in S versus NS at 0, 60 and 75 min (144.64–202.78 vs. 107.70–134.20 mg·dL−1) but not insulin. During aerobic exercise, RQ was 5% greater (0.90 vs. 0.86) (P = 0.039), and FAT oxidation was 35% lower at 6–8 min (0.003 vs. 0.005 g·min−1·kg−1) (P = 0.033) in S versus NS. During anaerobic exercise, CHO oxidation was 31% greater in NS versus S at 60–80% time to exhaustion (0.011 vs. 0.007 g·min−1·kg−1) (P = 0.015). Per cent contribution to energy expenditure was greater in S for CHO but lower for FAT at 0 (CHO: 22% vs. 10%; FAT: 78% vs. 91%) and 120–180 min (CHO: 35–42% vs. 17–25%; FAT: 58–65% vs. 75%–84%) (P = 0.003–0.046) at rest and 6–8 min during aerobic exercise (CHO: 70% vs. 57%; FAT: 30% vs. 45%) (P = 0.046). Conclusions The data show differences in skeletal muscle energy metabolism and substrate utilization between S and NS at rest, transitioning from fasted to fed state, and during exercise. Compared with NS, S displayed a diminished ability to adapt fuel utilization in response to feeding and exercise, reflecting metabolic inflexibility. Impaired metabolic flexibility could be a mechanism underlying the losses of strength and physical function accompanying sarcopenia. |
| first_indexed | 2024-04-24T08:18:37Z |
| format | Article |
| id | doaj.art-d17c8f6b4c2e448cb25dffcb3a10e7d6 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-24T08:18:37Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-d17c8f6b4c2e448cb25dffcb3a10e7d62024-04-17T02:45:41ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092022-04-011321224123710.1002/jcsm.12932Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adultsMarni E. Shoemaker0Suzette L. Pereira1Vikkie A. Mustad2Zachary M. Gillen3Brianna D. McKay4Jose M. Lopez‐Pedrosa5Ricardo Rueda6Joel T. Cramer7College of Health Sciences The University of Texas at El Paso El Paso TX USAAbbott Nutrition Columbus OH USANutrition Science Consulting LLC Galena OH USADepartment of Kinesiology Mississippi State University Mississippi State MS USADepartment of Health Professions Creighton University School of Medicine Omaha NE USAAbbott Nutrition R&D Granada SpainAbbott Nutrition R&D Granada SpainCollege of Health Sciences The University of Texas at El Paso El Paso TX USAAbstract Background Metabolic flexibility is the ability of skeletal muscle to adapt fuel utilization to the demand for fuel sources [carbohydrates (CHO) and fats (FAT)]. The purpose of this study was to explore muscle energy metabolism and metabolic flexibility under various conditions in sarcopenic (S) versus nonsarcopenic (NS) older adults. Methods Twenty‐two older adults aged 65 years or older were categorized as NS [n = 11; mean ± standard deviation (SD); age = 73.5 ± 6.0 years (males, n = 5; females, n = 6)] or S [n = 11; 81.2 ± 10.5 years (males, n = 6; females, n = 5) based on handgrip strength, body composition and physical performance. Indirect calorimetry was recorded before and after consumption of a high‐CHO meal and during aerobic and anaerobic exercise. Respiratory quotient (RQ), CHO and FAT oxidation were assessed. Venous blood samples were collected for glucose and insulin concentrations. Results At rest, compared with NS, S exhibited a 5–8% higher RQ at 0 (0.72 vs. 0.76) and 120 (0.77 vs. 0.82), 150 (0.76 vs. 0.80), and 180 min (0.74 vs. 0.80) (P = 0.002–0.025); 59–195% higher CHO oxidation at 0, 120, and 180 min (0.0004–0.002 vs. 0.001–0.002 g·min−1·kg‐1) (P = 0.010–0.047); and 20–31% lower FAT oxidation at 0, 15, and 90–180 min (0.0009–0.0022 vs. 0.0011–0.002 g·min−1·kg−1) (P = 0.004–0.038). Glucose levels were significantly elevated in S versus NS at 0, 60 and 75 min (144.64–202.78 vs. 107.70–134.20 mg·dL−1) but not insulin. During aerobic exercise, RQ was 5% greater (0.90 vs. 0.86) (P = 0.039), and FAT oxidation was 35% lower at 6–8 min (0.003 vs. 0.005 g·min−1·kg−1) (P = 0.033) in S versus NS. During anaerobic exercise, CHO oxidation was 31% greater in NS versus S at 60–80% time to exhaustion (0.011 vs. 0.007 g·min−1·kg−1) (P = 0.015). Per cent contribution to energy expenditure was greater in S for CHO but lower for FAT at 0 (CHO: 22% vs. 10%; FAT: 78% vs. 91%) and 120–180 min (CHO: 35–42% vs. 17–25%; FAT: 58–65% vs. 75%–84%) (P = 0.003–0.046) at rest and 6–8 min during aerobic exercise (CHO: 70% vs. 57%; FAT: 30% vs. 45%) (P = 0.046). Conclusions The data show differences in skeletal muscle energy metabolism and substrate utilization between S and NS at rest, transitioning from fasted to fed state, and during exercise. Compared with NS, S displayed a diminished ability to adapt fuel utilization in response to feeding and exercise, reflecting metabolic inflexibility. Impaired metabolic flexibility could be a mechanism underlying the losses of strength and physical function accompanying sarcopenia.https://doi.org/10.1002/jcsm.12932Metabolic flexibilitySarcopeniaCarbohydrate oxidationFat oxidationAgeingMetabolism |
| spellingShingle | Marni E. Shoemaker Suzette L. Pereira Vikkie A. Mustad Zachary M. Gillen Brianna D. McKay Jose M. Lopez‐Pedrosa Ricardo Rueda Joel T. Cramer Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults Journal of Cachexia, Sarcopenia and Muscle Metabolic flexibility Sarcopenia Carbohydrate oxidation Fat oxidation Ageing Metabolism |
| title | Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults |
| title_full | Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults |
| title_fullStr | Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults |
| title_full_unstemmed | Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults |
| title_short | Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults |
| title_sort | differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults |
| topic | Metabolic flexibility Sarcopenia Carbohydrate oxidation Fat oxidation Ageing Metabolism |
| url | https://doi.org/10.1002/jcsm.12932 |
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