Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis
With this review, we provide the state of the art concerning brain metastases (BMs) from ovarian cancer (OC), a rare condition. Clinical, pathological, and molecular features, treatment options, and future perspectives are comprehensively discussed. Overall, a diagnosis of high-grade serous OC and a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/8/2156 |
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| author | Fulvio Borella Luca Bertero Antonio Morrone Alessandro Gambella Marialuisa Bovetti Stefano Cosma Andrea Carosso Dionyssios Katsaros Silvia Gemmiti Mario Preti Giorgio Valabrega Giulia Scotto Paola Cassoni Chiara Benedetto |
| author_facet | Fulvio Borella Luca Bertero Antonio Morrone Alessandro Gambella Marialuisa Bovetti Stefano Cosma Andrea Carosso Dionyssios Katsaros Silvia Gemmiti Mario Preti Giorgio Valabrega Giulia Scotto Paola Cassoni Chiara Benedetto |
| author_sort | Fulvio Borella |
| collection | DOAJ |
| description | With this review, we provide the state of the art concerning brain metastases (BMs) from ovarian cancer (OC), a rare condition. Clinical, pathological, and molecular features, treatment options, and future perspectives are comprehensively discussed. Overall, a diagnosis of high-grade serous OC and an advanced disease stage are common features among patients who develop brain metastases. <i>BRCA1</i> and <i>BRCA2</i> gene mutations, as well as the expression of androgen receptors in the primary tumor, are emerging risk and prognostic factors which could allow one to identify categories of patients at greater risk of BMs, who could benefit from a tailored follow-up. Based on present data, a multidisciplinary approach combining surgery, radiotherapy, and chemotherapy seem to be the best approach for patients with good performance status, although the median overall survival (<1 year) remains largely disappointing. Hopefully, novel therapeutic avenues are being explored, like PARP inhibitors and immunotherapy, based on our improved knowledge regarding tumor biology, but further investigation is warranted. |
| first_indexed | 2024-03-10T17:59:31Z |
| format | Article |
| id | doaj.art-d17ca5ac51184e44a09524f9b36ceba7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T17:59:31Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d17ca5ac51184e44a09524f9b36ceba72023-11-20T09:00:42ZengMDPI AGCancers2072-66942020-08-01128215610.3390/cancers12082156Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and PrognosisFulvio Borella0Luca Bertero1Antonio Morrone2Alessandro Gambella3Marialuisa Bovetti4Stefano Cosma5Andrea Carosso6Dionyssios Katsaros7Silvia Gemmiti8Mario Preti9Giorgio Valabrega10Giulia Scotto11Paola Cassoni12Chiara Benedetto13Department of Surgical Sciences, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Surgical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Surgical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Surgical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Surgical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Surgical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Surgical Sciences, University of Turin, 10126 Turin, ItalyCandiolo Cancer Institute, FPO-IRCCS, Strada Provinciale 142 Km 3.95, Candiolo, 10060 Torino, ItalyCandiolo Cancer Institute, FPO-IRCCS, Strada Provinciale 142 Km 3.95, Candiolo, 10060 Torino, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Surgical Sciences, University of Turin, 10126 Turin, ItalyWith this review, we provide the state of the art concerning brain metastases (BMs) from ovarian cancer (OC), a rare condition. Clinical, pathological, and molecular features, treatment options, and future perspectives are comprehensively discussed. Overall, a diagnosis of high-grade serous OC and an advanced disease stage are common features among patients who develop brain metastases. <i>BRCA1</i> and <i>BRCA2</i> gene mutations, as well as the expression of androgen receptors in the primary tumor, are emerging risk and prognostic factors which could allow one to identify categories of patients at greater risk of BMs, who could benefit from a tailored follow-up. Based on present data, a multidisciplinary approach combining surgery, radiotherapy, and chemotherapy seem to be the best approach for patients with good performance status, although the median overall survival (<1 year) remains largely disappointing. Hopefully, novel therapeutic avenues are being explored, like PARP inhibitors and immunotherapy, based on our improved knowledge regarding tumor biology, but further investigation is warranted.https://www.mdpi.com/2072-6694/12/8/2156brain metastasesovarian cancerBRCAtreatmentmanagementpathology |
| spellingShingle | Fulvio Borella Luca Bertero Antonio Morrone Alessandro Gambella Marialuisa Bovetti Stefano Cosma Andrea Carosso Dionyssios Katsaros Silvia Gemmiti Mario Preti Giorgio Valabrega Giulia Scotto Paola Cassoni Chiara Benedetto Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis Cancers brain metastases ovarian cancer BRCA treatment management pathology |
| title | Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis |
| title_full | Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis |
| title_fullStr | Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis |
| title_full_unstemmed | Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis |
| title_short | Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis |
| title_sort | brain metastases from ovarian cancer current evidence in diagnosis treatment and prognosis |
| topic | brain metastases ovarian cancer BRCA treatment management pathology |
| url | https://www.mdpi.com/2072-6694/12/8/2156 |
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