Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome
Being born small or large for gestational age (SGA and LGA, respectively), combined with suboptimal early postnatal outcomes, can entail future metabolic alterations. The exact mechanisms underlying such risks are not fully understood. Lipids are a highly diverse class of molecules that perform mult...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/18/3760 |
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| author | Carolina Gonzalez-Riano Marcelo Santos Marta Díaz Cristina García-Beltran Carles Lerin Coral Barbas Lourdes Ibáñez David Sánchez-Infantes |
| author_facet | Carolina Gonzalez-Riano Marcelo Santos Marta Díaz Cristina García-Beltran Carles Lerin Coral Barbas Lourdes Ibáñez David Sánchez-Infantes |
| author_sort | Carolina Gonzalez-Riano |
| collection | DOAJ |
| description | Being born small or large for gestational age (SGA and LGA, respectively), combined with suboptimal early postnatal outcomes, can entail future metabolic alterations. The exact mechanisms underlying such risks are not fully understood. Lipids are a highly diverse class of molecules that perform multiple structural and metabolic functions. Dysregulation of lipid metabolism underlies the onset and progression of many disorders leading to pathological states. The aim of this pilot study was to investigate the relationships between birth weight, early postnatal outcomes, and cord blood serum lipidomes. We performed a non-targeted lipidomics-based approach to ascertain differences in cord blood lipid species among SGA, LGA, and appropriate-for-GA (AGA) newborns. Moreover, we longitudinally assessed (at birth and at ages of 4 and 12 months) weight and length, body composition (DXA), and clinical parameters. We disclosed distinct cord blood lipidome patterns in SGA, LGA, and AGA newborns; target lipid species distinctly modulated in each SGA, AGA, and LGA individual were associated with parameters related to growth and glucose homeostasis. The distinct lipidome patterns observed in SGA, AGA, and LGA newborns may play a role in adipose tissue remodeling and future metabolic risks. Maternal dietary interventions may potentially provide long-term benefits for the metabolic health of the offspring. |
| first_indexed | 2024-03-09T22:56:34Z |
| format | Article |
| id | doaj.art-d17cff1fcb33431e9f95265772c36b04 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:56:34Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d17cff1fcb33431e9f95265772c36b042023-11-23T18:11:23ZengMDPI AGNutrients2072-66432022-09-011418376010.3390/nu14183760Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood LipidomeCarolina Gonzalez-Riano0Marcelo Santos1Marta Díaz2Cristina García-Beltran3Carles Lerin4Coral Barbas5Lourdes Ibáñez6David Sánchez-Infantes7Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, SpainEndocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, SpainEndocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, SpainEndocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, SpainEndocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, SpainCentro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, SpainEndocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, SpainCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), 28029 Madrid, SpainBeing born small or large for gestational age (SGA and LGA, respectively), combined with suboptimal early postnatal outcomes, can entail future metabolic alterations. The exact mechanisms underlying such risks are not fully understood. Lipids are a highly diverse class of molecules that perform multiple structural and metabolic functions. Dysregulation of lipid metabolism underlies the onset and progression of many disorders leading to pathological states. The aim of this pilot study was to investigate the relationships between birth weight, early postnatal outcomes, and cord blood serum lipidomes. We performed a non-targeted lipidomics-based approach to ascertain differences in cord blood lipid species among SGA, LGA, and appropriate-for-GA (AGA) newborns. Moreover, we longitudinally assessed (at birth and at ages of 4 and 12 months) weight and length, body composition (DXA), and clinical parameters. We disclosed distinct cord blood lipidome patterns in SGA, LGA, and AGA newborns; target lipid species distinctly modulated in each SGA, AGA, and LGA individual were associated with parameters related to growth and glucose homeostasis. The distinct lipidome patterns observed in SGA, AGA, and LGA newborns may play a role in adipose tissue remodeling and future metabolic risks. Maternal dietary interventions may potentially provide long-term benefits for the metabolic health of the offspring.https://www.mdpi.com/2072-6643/14/18/3760lipidomicsLC–MSlipid metabolismgestational agebirth weightcord blood serum |
| spellingShingle | Carolina Gonzalez-Riano Marcelo Santos Marta Díaz Cristina García-Beltran Carles Lerin Coral Barbas Lourdes Ibáñez David Sánchez-Infantes Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome Nutrients lipidomics LC–MS lipid metabolism gestational age birth weight cord blood serum |
| title | Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome |
| title_full | Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome |
| title_fullStr | Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome |
| title_full_unstemmed | Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome |
| title_short | Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome |
| title_sort | birth weight and early postnatal outcomes association with the cord blood lipidome |
| topic | lipidomics LC–MS lipid metabolism gestational age birth weight cord blood serum |
| url | https://www.mdpi.com/2072-6643/14/18/3760 |
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