Transmissibility of Mycobacterium pinnipedii in a murine model
The causative agent of tuberculosis in pinnipeds is Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex (MTC). The natural hosts are pinnipeds; however, other non-marine mammals, including humans, can also be infected. The transmissibility of a pathogen is related to its vir...
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Frontiers Media S.A.
2024-03-01
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Series: | Frontiers in Cellular and Infection Microbiology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1328981/full |
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author | María Jimena Marfil Federico Carlos Blanco María Alejandra Colombatti Olivieri María Emilia Eirin Martín José Zumárraga |
author_facet | María Jimena Marfil Federico Carlos Blanco María Alejandra Colombatti Olivieri María Emilia Eirin Martín José Zumárraga |
author_sort | María Jimena Marfil |
collection | DOAJ |
description | The causative agent of tuberculosis in pinnipeds is Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex (MTC). The natural hosts are pinnipeds; however, other non-marine mammals, including humans, can also be infected. The transmissibility of a pathogen is related to its virulence. The transmissibility of a M. pinnipedii strain (i.e., 1856) was investigated in a murine model and compared with that of two Mycobacterium bovis strains (i.e., 534 and 04-303) with different reported virulence. Non-inoculated mice (sentinels) were co-housed with intratracheally inoculated mice. Detailed inspection of mice to search for visible tuberculosis lesions in the lungs and spleen was performed, and bacillus viability at 30, 60, and 90 days post-inoculation (dpi) was assayed. A transmissibility of 100% was recorded at 30 dpi in sentinel mice co-housed with the inoculated mice from the M. pinnipedii and M. bovis 04-303 groups, as evidenced by the recovery of viable M. pinnipedii and M. bovis from the lungs of sentinel mice. Mice inoculated with M. pinnipedii (1856) and M. bovis (534) survived until euthanized, whereas five of the M. bovis 04-303-inoculated mice died at 17 dpi. This study constitutes the first report of the transmissibility of a M. pinnipedii strain in mice and confirms the utility of this experimental model to study virulence features such as the transmission of poorly characterized MTC species. |
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language | English |
last_indexed | 2024-04-24T17:37:43Z |
publishDate | 2024-03-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Cellular and Infection Microbiology |
spelling | doaj.art-d180a744385a42f0afc603b4a11677bb2024-03-28T04:28:13ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-03-011410.3389/fcimb.2024.13289811328981Transmissibility of Mycobacterium pinnipedii in a murine modelMaría Jimena Marfil0Federico Carlos Blanco1María Alejandra Colombatti Olivieri2María Emilia Eirin3Martín José Zumárraga4Cátedra de Enfermedades Infecciosas, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Ciudad Autónoma d Buenos Aires, ArgentinaInstituto de Agrobiotecnología y Biología Molecular (IABIMO) UEDD CONICET-Instituto Nacional de Tecnología Agropecuaria, Argentina (INTA), Centro de Investigación en Cs. Veterinarias y Agronómicas (CICVyA)-CNIA, Hurlingham, Buenos Aires, ArgentinaInstituto de Agrobiotecnología y Biología Molecular (IABIMO) UEDD CONICET-Instituto Nacional de Tecnología Agropecuaria, Argentina (INTA), Centro de Investigación en Cs. Veterinarias y Agronómicas (CICVyA)-CNIA, Hurlingham, Buenos Aires, ArgentinaInstituto de Agrobiotecnología y Biología Molecular (IABIMO) UEDD CONICET-Instituto Nacional de Tecnología Agropecuaria, Argentina (INTA), Centro de Investigación en Cs. Veterinarias y Agronómicas (CICVyA)-CNIA, Hurlingham, Buenos Aires, ArgentinaInstituto de Agrobiotecnología y Biología Molecular (IABIMO) UEDD CONICET-Instituto Nacional de Tecnología Agropecuaria, Argentina (INTA), Centro de Investigación en Cs. Veterinarias y Agronómicas (CICVyA)-CNIA, Hurlingham, Buenos Aires, ArgentinaThe causative agent of tuberculosis in pinnipeds is Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex (MTC). The natural hosts are pinnipeds; however, other non-marine mammals, including humans, can also be infected. The transmissibility of a pathogen is related to its virulence. The transmissibility of a M. pinnipedii strain (i.e., 1856) was investigated in a murine model and compared with that of two Mycobacterium bovis strains (i.e., 534 and 04-303) with different reported virulence. Non-inoculated mice (sentinels) were co-housed with intratracheally inoculated mice. Detailed inspection of mice to search for visible tuberculosis lesions in the lungs and spleen was performed, and bacillus viability at 30, 60, and 90 days post-inoculation (dpi) was assayed. A transmissibility of 100% was recorded at 30 dpi in sentinel mice co-housed with the inoculated mice from the M. pinnipedii and M. bovis 04-303 groups, as evidenced by the recovery of viable M. pinnipedii and M. bovis from the lungs of sentinel mice. Mice inoculated with M. pinnipedii (1856) and M. bovis (534) survived until euthanized, whereas five of the M. bovis 04-303-inoculated mice died at 17 dpi. This study constitutes the first report of the transmissibility of a M. pinnipedii strain in mice and confirms the utility of this experimental model to study virulence features such as the transmission of poorly characterized MTC species.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1328981/fullM. pinnipediiM. bovistransmissibilitymiceexperimental model |
spellingShingle | María Jimena Marfil Federico Carlos Blanco María Alejandra Colombatti Olivieri María Emilia Eirin Martín José Zumárraga Transmissibility of Mycobacterium pinnipedii in a murine model Frontiers in Cellular and Infection Microbiology M. pinnipedii M. bovis transmissibility mice experimental model |
title | Transmissibility of Mycobacterium pinnipedii in a murine model |
title_full | Transmissibility of Mycobacterium pinnipedii in a murine model |
title_fullStr | Transmissibility of Mycobacterium pinnipedii in a murine model |
title_full_unstemmed | Transmissibility of Mycobacterium pinnipedii in a murine model |
title_short | Transmissibility of Mycobacterium pinnipedii in a murine model |
title_sort | transmissibility of mycobacterium pinnipedii in a murine model |
topic | M. pinnipedii M. bovis transmissibility mice experimental model |
url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1328981/full |
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