Graphene-Related Nanomaterials for Biomedical Applications
This paper builds on the context and recent progress on the control, reproducibility, and limitations of using graphene and graphene-related materials (GRMs) in biomedical applications. The review describes the human hazard assessment of GRMs in in vitro and in vivo studies, highlights the compositi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/6/1092 |
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| author | Andreea-Isabela Lazăr Kimia Aghasoleimani Anna Semertsidou Jahnavi Vyas Alin-Lucian Roșca Denisa Ficai Anton Ficai |
| author_facet | Andreea-Isabela Lazăr Kimia Aghasoleimani Anna Semertsidou Jahnavi Vyas Alin-Lucian Roșca Denisa Ficai Anton Ficai |
| author_sort | Andreea-Isabela Lazăr |
| collection | DOAJ |
| description | This paper builds on the context and recent progress on the control, reproducibility, and limitations of using graphene and graphene-related materials (GRMs) in biomedical applications. The review describes the human hazard assessment of GRMs in in vitro and in vivo studies, highlights the composition–structure–activity relationships that cause toxicity for these substances, and identifies the key parameters that determine the activation of their biological effects. GRMs are designed to offer the advantage of facilitating unique biomedical applications that impact different techniques in medicine, especially in neuroscience. Due to the increasing utilization of GRMs, there is a need to comprehensively assess the potential impact of these materials on human health. Various outcomes associated with GRMs, including biocompatibility, biodegradability, beneficial effects on cell proliferation, differentiation rates, apoptosis, necrosis, autophagy, oxidative stress, physical destruction, DNA damage, and inflammatory responses, have led to an increasing interest in these regenerative nanostructured materials. Considering the existence of graphene-related nanomaterials with different physicochemical properties, the materials are expected to exhibit unique modes of interactions with biomolecules, cells, and tissues depending on their size, chemical composition, and hydrophil-to-hydrophobe ratio. Understanding such interactions is crucial from two perspectives, namely, from the perspectives of their toxicity and biological uses. The main aim of this study is to assess and tune the diverse properties that must be considered when planning biomedical applications. These properties include flexibility, transparency, surface chemistry (hydrophil–hydrophobe ratio), thermoelectrical conductibility, loading and release capacity, and biocompatibility. |
| first_indexed | 2024-03-11T06:05:33Z |
| format | Article |
| id | doaj.art-d181ced245c6447bbf7cebe44a92e7cf |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T06:05:33Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-d181ced245c6447bbf7cebe44a92e7cf2023-11-17T13:01:26ZengMDPI AGNanomaterials2079-49912023-03-01136109210.3390/nano13061092Graphene-Related Nanomaterials for Biomedical ApplicationsAndreea-Isabela Lazăr0Kimia Aghasoleimani1Anna Semertsidou2Jahnavi Vyas3Alin-Lucian Roșca4Denisa Ficai5Anton Ficai6Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu St. 1–7, 011061 Bucharest, RomaniaUniversity of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UKCharles River Laboratories, Margate, Manston Road, Kent CT9 4LT, UKDrug Development Solution, Newmarket road, Ely, CB7 5WW, UKNational Centre for Food Safety, University Politehnica of Bucharest, Spl. Independentei 313, 060042 Bucharest, RomaniaNational Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, Spl. Independentei 313, 060042 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu St. 1–7, 011061 Bucharest, RomaniaThis paper builds on the context and recent progress on the control, reproducibility, and limitations of using graphene and graphene-related materials (GRMs) in biomedical applications. The review describes the human hazard assessment of GRMs in in vitro and in vivo studies, highlights the composition–structure–activity relationships that cause toxicity for these substances, and identifies the key parameters that determine the activation of their biological effects. GRMs are designed to offer the advantage of facilitating unique biomedical applications that impact different techniques in medicine, especially in neuroscience. Due to the increasing utilization of GRMs, there is a need to comprehensively assess the potential impact of these materials on human health. Various outcomes associated with GRMs, including biocompatibility, biodegradability, beneficial effects on cell proliferation, differentiation rates, apoptosis, necrosis, autophagy, oxidative stress, physical destruction, DNA damage, and inflammatory responses, have led to an increasing interest in these regenerative nanostructured materials. Considering the existence of graphene-related nanomaterials with different physicochemical properties, the materials are expected to exhibit unique modes of interactions with biomolecules, cells, and tissues depending on their size, chemical composition, and hydrophil-to-hydrophobe ratio. Understanding such interactions is crucial from two perspectives, namely, from the perspectives of their toxicity and biological uses. The main aim of this study is to assess and tune the diverse properties that must be considered when planning biomedical applications. These properties include flexibility, transparency, surface chemistry (hydrophil–hydrophobe ratio), thermoelectrical conductibility, loading and release capacity, and biocompatibility.https://www.mdpi.com/2079-4991/13/6/1092graphene-related (nano) materialbionanocompositestimuli-responsive drug-delivery systembiodegradabilitytissue engineeringneuronal regeneration |
| spellingShingle | Andreea-Isabela Lazăr Kimia Aghasoleimani Anna Semertsidou Jahnavi Vyas Alin-Lucian Roșca Denisa Ficai Anton Ficai Graphene-Related Nanomaterials for Biomedical Applications Nanomaterials graphene-related (nano) material bionanocomposite stimuli-responsive drug-delivery system biodegradability tissue engineering neuronal regeneration |
| title | Graphene-Related Nanomaterials for Biomedical Applications |
| title_full | Graphene-Related Nanomaterials for Biomedical Applications |
| title_fullStr | Graphene-Related Nanomaterials for Biomedical Applications |
| title_full_unstemmed | Graphene-Related Nanomaterials for Biomedical Applications |
| title_short | Graphene-Related Nanomaterials for Biomedical Applications |
| title_sort | graphene related nanomaterials for biomedical applications |
| topic | graphene-related (nano) material bionanocomposite stimuli-responsive drug-delivery system biodegradability tissue engineering neuronal regeneration |
| url | https://www.mdpi.com/2079-4991/13/6/1092 |
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