Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemica...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455921002527 |
| _version_ | 1818822974892933120 |
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| author | Semra Eroglu Elcin Kal Cakmakliogullari |
| author_facet | Semra Eroglu Elcin Kal Cakmakliogullari |
| author_sort | Semra Eroglu |
| collection | DOAJ |
| description | Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemical, and hormonal parameters, and serum adiponectin and IL-36α levels of the patients were evaluated. Results: The serum IL-36α levels of the PCOS patients were significantly lower when compared to the control group, despite a similar mean body mass index (BMI) (P = 0.000). The adiponectin levels were significantly lower in the obese PCOS group when compared to the obese control group (P = 0.03). The plasma IL-36α level was positively correlated with adiponectin level, but negatively correlated with the serum LH level (P = 0.000 and P = 0.004, respectively). Using receiver operating characteristic analysis, the cut-off value of IL-36α was calculated as 0.815 for PCOS. In the multiple binary logistic regression analysis, IL-36α (OR [95% CI] 0.432 [0.303, 0.616], P < 0.001) and adiponectin (OR [95% CI] 1.044 [1.005, 1.084], P = 0.028) were determined to be significantly associated with PCOS. Conclusion: A reduced IL-36α level may play a role in the pathogenesis of ovulatory disfunction and insulin resistance in PCOS patients. Further studies are needed to understand the pathogenic and clinical significance of the IL-36 system in PCOS. |
| first_indexed | 2024-12-18T23:32:37Z |
| format | Article |
| id | doaj.art-d18354ad8d6544e9adb046c087856c83 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-18T23:32:37Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-d18354ad8d6544e9adb046c087856c832022-12-21T20:47:38ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592021-11-0160610181022Decreased serum profile of the interleukin-36α in polycystic ovary syndromeSemra Eroglu0Elcin Kal Cakmakliogullari1Department of Gynecology and Obstetrics, Samsun University, Konya, Turkey; Corresponding author. Samsun University, Department of Gynecology and Obstetrics, Lise Street, No: 83, Samsun, Turkey. Fax: +90 3622309100.Department of Microbiology, Karabuk University, Karabuk, TurkeyObjective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemical, and hormonal parameters, and serum adiponectin and IL-36α levels of the patients were evaluated. Results: The serum IL-36α levels of the PCOS patients were significantly lower when compared to the control group, despite a similar mean body mass index (BMI) (P = 0.000). The adiponectin levels were significantly lower in the obese PCOS group when compared to the obese control group (P = 0.03). The plasma IL-36α level was positively correlated with adiponectin level, but negatively correlated with the serum LH level (P = 0.000 and P = 0.004, respectively). Using receiver operating characteristic analysis, the cut-off value of IL-36α was calculated as 0.815 for PCOS. In the multiple binary logistic regression analysis, IL-36α (OR [95% CI] 0.432 [0.303, 0.616], P < 0.001) and adiponectin (OR [95% CI] 1.044 [1.005, 1.084], P = 0.028) were determined to be significantly associated with PCOS. Conclusion: A reduced IL-36α level may play a role in the pathogenesis of ovulatory disfunction and insulin resistance in PCOS patients. Further studies are needed to understand the pathogenic and clinical significance of the IL-36 system in PCOS.http://www.sciencedirect.com/science/article/pii/S1028455921002527Polycystic ovary syndromeObesityInterleukin-36Adiponectin |
| spellingShingle | Semra Eroglu Elcin Kal Cakmakliogullari Decreased serum profile of the interleukin-36α in polycystic ovary syndrome Taiwanese Journal of Obstetrics & Gynecology Polycystic ovary syndrome Obesity Interleukin-36 Adiponectin |
| title | Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
| title_full | Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
| title_fullStr | Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
| title_full_unstemmed | Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
| title_short | Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
| title_sort | decreased serum profile of the interleukin 36α in polycystic ovary syndrome |
| topic | Polycystic ovary syndrome Obesity Interleukin-36 Adiponectin |
| url | http://www.sciencedirect.com/science/article/pii/S1028455921002527 |
| work_keys_str_mv | AT semraeroglu decreasedserumprofileoftheinterleukin36ainpolycysticovarysyndrome AT elcinkalcakmakliogullari decreasedserumprofileoftheinterleukin36ainpolycysticovarysyndrome |