Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

The formulation of arylpropionic acid derivatives (profens), which are poorly soluble Biopharmaceutical Classification System (BCS) Type II drugs, has a strong impact on their therapeutic action. This article shows that heat-treated powder mixtures of free acid profens with high surface area Cladoph...

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Bibliographic Details
Main Authors: Athanasios Mantas, Valentine Labbe, Irena Loryan, Albert Mihranyan
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Pharmaceutics
Subjects:
ketoprofen
flurbiprofen
naproxen
bioavailability
Cladophora cellulose
Online Access:https://www.mdpi.com/1999-4923/11/2/68

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