Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15-20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in so...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-12-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/370302 |
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| author | Jorge Ocampo-Garza Maira Elizabeth Herz-Ruelas Elias Eugenio González-Lopez Eric Eduardo Mendoza-Oviedo Juana Irma Garza-Chapa Sonia Sofía Ocampo-Garza Norma Elizabeth Vázquez-Herrera Ivett Miranda-Maldonado Jorge Ocampo-Candiani |
| author_facet | Jorge Ocampo-Garza Maira Elizabeth Herz-Ruelas Elias Eugenio González-Lopez Eric Eduardo Mendoza-Oviedo Juana Irma Garza-Chapa Sonia Sofía Ocampo-Garza Norma Elizabeth Vázquez-Herrera Ivett Miranda-Maldonado Jorge Ocampo-Candiani |
| author_sort | Jorge Ocampo-Garza |
| collection | DOAJ |
| description | Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15-20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules, papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of AITL was confirmed by an axillary lymph node biopsy, which was also positive for Epstein-Barr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles. |
| first_indexed | 2024-12-20T10:16:20Z |
| format | Article |
| id | doaj.art-d1835d15741b423ea6fd70523de5ca9d |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-20T10:16:20Z |
| publishDate | 2014-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-d1835d15741b423ea6fd70523de5ca9d2022-12-21T19:44:04ZengKarger PublishersCase Reports in Dermatology1662-65672014-12-016329129510.1159/000370302370302Angioimmunoblastic T-Cell Lymphoma: A Diagnostic ChallengeJorge Ocampo-GarzaMaira Elizabeth Herz-RuelasElias Eugenio González-LopezEric Eduardo Mendoza-OviedoJuana Irma Garza-ChapaSonia Sofía Ocampo-GarzaNorma Elizabeth Vázquez-HerreraIvett Miranda-MaldonadoJorge Ocampo-CandianiAngioimmunoblastic T-cell lymphoma (AITL) accounts for 15-20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules, papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of AITL was confirmed by an axillary lymph node biopsy, which was also positive for Epstein-Barr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles.http://www.karger.com/Article/FullText/370302LymphomaAngioimmunoblastic T-cell lymphomaCutaneous involvementEpstein-Barr virus |
| spellingShingle | Jorge Ocampo-Garza Maira Elizabeth Herz-Ruelas Elias Eugenio González-Lopez Eric Eduardo Mendoza-Oviedo Juana Irma Garza-Chapa Sonia Sofía Ocampo-Garza Norma Elizabeth Vázquez-Herrera Ivett Miranda-Maldonado Jorge Ocampo-Candiani Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge Case Reports in Dermatology Lymphoma Angioimmunoblastic T-cell lymphoma Cutaneous involvement Epstein-Barr virus |
| title | Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge |
| title_full | Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge |
| title_fullStr | Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge |
| title_full_unstemmed | Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge |
| title_short | Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge |
| title_sort | angioimmunoblastic t cell lymphoma a diagnostic challenge |
| topic | Lymphoma Angioimmunoblastic T-cell lymphoma Cutaneous involvement Epstein-Barr virus |
| url | http://www.karger.com/Article/FullText/370302 |
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