N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens
During evolution, both human and plant pathogens have evolved to utilize a diverse range of carbon sources. N-acetylglucosamine (GlcNAc), an amino sugar, is one of the major carbon sources utilized by several human and phytopathogens. GlcNAc regulates the expression of many virulence genes of pathog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/2/64 |
| _version_ | 1797482695431815168 |
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| author | Sekhu Ansari Vinay Kumar Dharmendra Nath Bhatt Mohammad Irfan Asis Datta |
| author_facet | Sekhu Ansari Vinay Kumar Dharmendra Nath Bhatt Mohammad Irfan Asis Datta |
| author_sort | Sekhu Ansari |
| collection | DOAJ |
| description | During evolution, both human and plant pathogens have evolved to utilize a diverse range of carbon sources. N-acetylglucosamine (GlcNAc), an amino sugar, is one of the major carbon sources utilized by several human and phytopathogens. GlcNAc regulates the expression of many virulence genes of pathogens. In fact, GlcNAc catabolism is also involved in the regulation of virulence and pathogenesis of various human pathogens, including <i>Candida albicans</i>, <i>Vibrio cholerae</i>, <i>Leishmania donovani</i>, <i>Mycobacterium</i>, and phytopathogens such as <i>Magnaporthe oryzae</i>. Moreover, GlcNAc is also a well-known structural component of many bacterial and fungal pathogen cell walls, suggesting its possible role in cell signaling. Over the last few decades, many studies have been performed to study GlcNAc sensing, signaling, and metabolism to better understand the GlcNAc roles in pathogenesis in order to identify new drug targets. In this review, we provide recent insights into GlcNAc-mediated cell signaling and pathogenesis. Further, we describe how the GlcNAc metabolic pathway can be targeted to reduce the pathogens’ virulence in order to control the disease prevalence and crop productivity. |
| first_indexed | 2024-03-09T22:36:10Z |
| format | Article |
| id | doaj.art-d187a719e27841e1998d36d735b15727 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T22:36:10Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-d187a719e27841e1998d36d735b157272023-11-23T18:48:32ZengMDPI AGBioengineering2306-53542022-02-01926410.3390/bioengineering9020064N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant PathogensSekhu Ansari0Vinay Kumar1Dharmendra Nath Bhatt2Mohammad Irfan3Asis Datta4Division of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADepartment of Physiology and Cell Biology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USANational Institute of Plant Genome Research, Aruna Asaf Ali Road, New JNU Campus, New Delhi 110067, IndiaPlant Biology Section, School of Integrative Plant Sciences, Cornell University, Ithaca, New York, NY 14453, USANational Institute of Plant Genome Research, Aruna Asaf Ali Road, New JNU Campus, New Delhi 110067, IndiaDuring evolution, both human and plant pathogens have evolved to utilize a diverse range of carbon sources. N-acetylglucosamine (GlcNAc), an amino sugar, is one of the major carbon sources utilized by several human and phytopathogens. GlcNAc regulates the expression of many virulence genes of pathogens. In fact, GlcNAc catabolism is also involved in the regulation of virulence and pathogenesis of various human pathogens, including <i>Candida albicans</i>, <i>Vibrio cholerae</i>, <i>Leishmania donovani</i>, <i>Mycobacterium</i>, and phytopathogens such as <i>Magnaporthe oryzae</i>. Moreover, GlcNAc is also a well-known structural component of many bacterial and fungal pathogen cell walls, suggesting its possible role in cell signaling. Over the last few decades, many studies have been performed to study GlcNAc sensing, signaling, and metabolism to better understand the GlcNAc roles in pathogenesis in order to identify new drug targets. In this review, we provide recent insights into GlcNAc-mediated cell signaling and pathogenesis. Further, we describe how the GlcNAc metabolic pathway can be targeted to reduce the pathogens’ virulence in order to control the disease prevalence and crop productivity.https://www.mdpi.com/2306-5354/9/2/64N-AcetylglucosaminepathogensvirulencecolonizationNAG1DAC1 |
| spellingShingle | Sekhu Ansari Vinay Kumar Dharmendra Nath Bhatt Mohammad Irfan Asis Datta N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens Bioengineering N-Acetylglucosamine pathogens virulence colonization NAG1 DAC1 |
| title | N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens |
| title_full | N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens |
| title_fullStr | N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens |
| title_full_unstemmed | N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens |
| title_short | N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens |
| title_sort | n acetylglucosamine sensing and metabolic engineering for attenuating human and plant pathogens |
| topic | N-Acetylglucosamine pathogens virulence colonization NAG1 DAC1 |
| url | https://www.mdpi.com/2306-5354/9/2/64 |
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