A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein
The physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which...
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Mashhad University of Medical Sciences
2016-01-01
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Series: | Iranian Journal of Basic Medical Sciences |
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Online Access: | http://ijbms.mums.ac.ir/article_6408_620ebdfdfb45f513ce17002304ff0b9c.pdf |
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author | Maryam Mousavinezhad-Moghaddam Abbas Ali Amin Houshang Rafatpanah Seyed Abdol Rahim Rezaee |
author_facet | Maryam Mousavinezhad-Moghaddam Abbas Ali Amin Houshang Rafatpanah Seyed Abdol Rahim Rezaee |
author_sort | Maryam Mousavinezhad-Moghaddam |
collection | DOAJ |
description | The physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. CD200 and CD200R molecules are membrane proteins that their immunomodulatory effects are able to suppress inflammatory responses, particularly in the privilege sites such as CNS and eyes. Kaposi’s sarcoma-associated herpesvirus (KSHV), encodes a wide variety of immunoregulatory proteins which play central roles in modulating inflammatory and anti-inflammatory responses in favour of virus dissemination. One such protein is a homologue of the, encoded by open reading frame (ORF) K14 and therefore called vOX2. Based on its gene expression profile during the KSHV life cycle, it is hypothesised that vOX2 modulates host inflammatory responses. Moreover, it seems that vOX2 involves in cell adhesion and modulates innate immunity and promotes Th2 immune responses. In this review the activities of mammalian CD200 and KSHV CD200 in cell adhesion and immune system modulation are reviewed in the context of potential therapeutic agents. |
first_indexed | 2024-04-12T23:36:26Z |
format | Article |
id | doaj.art-d1881a96b03540ba883245f2da5de143 |
institution | Directory Open Access Journal |
issn | 2008-3866 2008-3874 |
language | English |
last_indexed | 2024-04-12T23:36:26Z |
publishDate | 2016-01-01 |
publisher | Mashhad University of Medical Sciences |
record_format | Article |
series | Iranian Journal of Basic Medical Sciences |
spelling | doaj.art-d1881a96b03540ba883245f2da5de1432022-12-22T03:12:09ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-01-011912136408A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory proteinMaryam Mousavinezhad-Moghaddam0Abbas Ali Amin1Houshang Rafatpanah2Seyed Abdol Rahim Rezaee3Department of Physiology, Biology Division, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, IranDepartment of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IranImmunology Research Centre, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, IranInflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranThe physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. CD200 and CD200R molecules are membrane proteins that their immunomodulatory effects are able to suppress inflammatory responses, particularly in the privilege sites such as CNS and eyes. Kaposi’s sarcoma-associated herpesvirus (KSHV), encodes a wide variety of immunoregulatory proteins which play central roles in modulating inflammatory and anti-inflammatory responses in favour of virus dissemination. One such protein is a homologue of the, encoded by open reading frame (ORF) K14 and therefore called vOX2. Based on its gene expression profile during the KSHV life cycle, it is hypothesised that vOX2 modulates host inflammatory responses. Moreover, it seems that vOX2 involves in cell adhesion and modulates innate immunity and promotes Th2 immune responses. In this review the activities of mammalian CD200 and KSHV CD200 in cell adhesion and immune system modulation are reviewed in the context of potential therapeutic agents.http://ijbms.mums.ac.ir/article_6408_620ebdfdfb45f513ce17002304ff0b9c.pdfCD200Immune modulationKSHVRGDvCD200vOX2 |
spellingShingle | Maryam Mousavinezhad-Moghaddam Abbas Ali Amin Houshang Rafatpanah Seyed Abdol Rahim Rezaee A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein Iranian Journal of Basic Medical Sciences CD200 Immune modulation KSHV RGD vCD200 vOX2 |
title | A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein |
title_full | A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein |
title_fullStr | A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein |
title_full_unstemmed | A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein |
title_short | A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein |
title_sort | new insight into viral proteins as immunomodulatory therapeutic agents kshv vox2 a homolog of human cd200 as a potent anti inflammatory protein |
topic | CD200 Immune modulation KSHV RGD vCD200 vOX2 |
url | http://ijbms.mums.ac.ir/article_6408_620ebdfdfb45f513ce17002304ff0b9c.pdf |
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