Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S]
Acute phase reaction (APR) is a systemic inflammation triggered by several conditions associated with lipid profile alterations. We evaluated whether APR also associates with changes in cholesterol synthesis and absorption, HDL structure, composition, and cholesterol efflux capacity (CEC). We analyz...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520335744 |
| _version_ | 1818726333653450752 |
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| author | Francesca Zimetti Stefano De Vuono Monica Gomaraschi Maria Pia Adorni Elda Favari Nicoletta Ronda Maria Anastasia Ricci Fabrizio Veglia Laura Calabresi Graziana Lupattelli |
| author_facet | Francesca Zimetti Stefano De Vuono Monica Gomaraschi Maria Pia Adorni Elda Favari Nicoletta Ronda Maria Anastasia Ricci Fabrizio Veglia Laura Calabresi Graziana Lupattelli |
| author_sort | Francesca Zimetti |
| collection | DOAJ |
| description | Acute phase reaction (APR) is a systemic inflammation triggered by several conditions associated with lipid profile alterations. We evaluated whether APR also associates with changes in cholesterol synthesis and absorption, HDL structure, composition, and cholesterol efflux capacity (CEC). We analyzed 59 subjects with APR related to infections, oncologic causes, or autoimmune diseases and 39 controls. We detected no difference in markers of cholesterol synthesis and absorption. Conversely, a significant reduction of LpA-I- and LpAI:AII-containing HDL (−28% and −44.8%, respectively) and of medium-sized HDL (−10.5%) occurred in APR. Total HDL CEC was impaired in APR subjects (−18%). Evaluating specific CEC pathways, we found significant reductions in CEC by aqueous diffusion and by the transporters scavenger receptor B-I and ABCG1 (−25.5, −41.1 and −30.4%, respectively). ABCA1-mediated CEC was not affected. Analyses adjusted for age and gender provided similar results. In addition, correcting for HDL-cholesterol (HDL-C) levels, the differences in aqueous diffusion total and ABCG1-CEC remained significant. APR subjects displayed higher levels of HDL serum amyloid A (+20-folds; P = 0.003). In conclusion, APR does not associate with cholesterol synthesis and absorption changes but with alterations of HDL composition and a marked impairment of HDL CEC, partly independent of HDL-C serum level reduction. |
| first_indexed | 2024-12-17T21:56:32Z |
| format | Article |
| id | doaj.art-d1884fe091c7488d863b9495444ab925 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T21:56:32Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-d1884fe091c7488d863b9495444ab9252022-12-21T21:31:07ZengElsevierJournal of Lipid Research0022-22752017-10-01581020512060Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S]Francesca Zimetti0Stefano De Vuono1Monica Gomaraschi2Maria Pia Adorni3Elda Favari4Nicoletta Ronda5Maria Anastasia Ricci6Fabrizio Veglia7Laura Calabresi8Graziana Lupattelli9To whom correspondence should be addressed. e-mail:; Department of Food and Drug, University of Parma, Parma, Italy; To whom correspondence should be addressed. e-mail:Department of Medicine, Internal Medicine, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, ItalyDipartimento di Scienze Farmacologiche e Biomolecolari, Centro E. Grossi Paoletti, Università degli Studi di Milano, Milano, ItalyDepartment of Food and Drug, University of Parma, Parma, ItalyDepartment of Food and Drug, University of Parma, Parma, ItalyDepartment of Food and Drug, University of Parma, Parma, ItalyDepartment of Medicine, Internal Medicine, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, ItalyIRCCS Cardiologico Monzino, Milano, ItalyDipartimento di Scienze Farmacologiche e Biomolecolari, Centro E. Grossi Paoletti, Università degli Studi di Milano, Milano, ItalyDepartment of Medicine, Internal Medicine, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, ItalyAcute phase reaction (APR) is a systemic inflammation triggered by several conditions associated with lipid profile alterations. We evaluated whether APR also associates with changes in cholesterol synthesis and absorption, HDL structure, composition, and cholesterol efflux capacity (CEC). We analyzed 59 subjects with APR related to infections, oncologic causes, or autoimmune diseases and 39 controls. We detected no difference in markers of cholesterol synthesis and absorption. Conversely, a significant reduction of LpA-I- and LpAI:AII-containing HDL (−28% and −44.8%, respectively) and of medium-sized HDL (−10.5%) occurred in APR. Total HDL CEC was impaired in APR subjects (−18%). Evaluating specific CEC pathways, we found significant reductions in CEC by aqueous diffusion and by the transporters scavenger receptor B-I and ABCG1 (−25.5, −41.1 and −30.4%, respectively). ABCA1-mediated CEC was not affected. Analyses adjusted for age and gender provided similar results. In addition, correcting for HDL-cholesterol (HDL-C) levels, the differences in aqueous diffusion total and ABCG1-CEC remained significant. APR subjects displayed higher levels of HDL serum amyloid A (+20-folds; P = 0.003). In conclusion, APR does not associate with cholesterol synthesis and absorption changes but with alterations of HDL composition and a marked impairment of HDL CEC, partly independent of HDL-C serum level reduction.http://www.sciencedirect.com/science/article/pii/S0022227520335744campesterolcholesterol absorptioncholesterol biosynthesischolesterol effluxHDL structureinflammation |
| spellingShingle | Francesca Zimetti Stefano De Vuono Monica Gomaraschi Maria Pia Adorni Elda Favari Nicoletta Ronda Maria Anastasia Ricci Fabrizio Veglia Laura Calabresi Graziana Lupattelli Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S] Journal of Lipid Research campesterol cholesterol absorption cholesterol biosynthesis cholesterol efflux HDL structure inflammation |
| title | Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S] |
| title_full | Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S] |
| title_fullStr | Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S] |
| title_full_unstemmed | Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S] |
| title_short | Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S] |
| title_sort | plasma cholesterol homeostasis hdl remodeling and function during the acute phase reaction s |
| topic | campesterol cholesterol absorption cholesterol biosynthesis cholesterol efflux HDL structure inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520335744 |
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