Gut microbiome: decision-makers in the microenvironment of colorectal cancer
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for the second most common cause of gastrointestinal tumors. As one of the intestinal barriers, gut bacteria form biofilm, participate in intestinal work, and form the living environment of intestinal cells. Met...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1299977/full |
| _version_ | 1797393427493552128 |
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| author | Jingrun Han Biao Zhang Biao Zhang Yongnian Zhang Tianyi Yin Yuying Cui Yuying Cui Yuying Cui Jinming Liu Yanfei Yang Huiyi Song Huiyi Song Huiyi Song Dong Shang Dong Shang Dong Shang |
| author_facet | Jingrun Han Biao Zhang Biao Zhang Yongnian Zhang Tianyi Yin Yuying Cui Yuying Cui Yuying Cui Jinming Liu Yanfei Yang Huiyi Song Huiyi Song Huiyi Song Dong Shang Dong Shang Dong Shang |
| author_sort | Jingrun Han |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for the second most common cause of gastrointestinal tumors. As one of the intestinal barriers, gut bacteria form biofilm, participate in intestinal work, and form the living environment of intestinal cells. Metagenomic next-generation sequencing (mNGS) of the gut bacteria in a large number of CRC patients has been established, enabling specific microbial signatures to be associated with colorectal adenomato-carcinoma. Gut bacteria are involved in both benign precursor lesions (polyps), in situ growth and metastasis of CRC. Therefore, the term tumorigenic bacteria was proposed in 2018, such as Escherichia coli, Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, etc. Meanwhile, bacteria toxins (such as cytolethal distending toxin (CDT), Colibactin (Clb), B. fragilis toxin) affect the tumor microenvironment and promote cancer occurrence and tumor immune escape. It is important to note that there are differences in the bacteria of different types of CRC. In this paper, the role of tumorigenic bacteria in the polyp-cancer transformation and the effects of their secreted toxins on the tumor microenvironment will be discussed, thereby further exploring new ideas for the prevention and treatment of CRC. |
| first_indexed | 2024-03-09T00:03:24Z |
| format | Article |
| id | doaj.art-d1886f8e33b44c6dbe120ab7a3e030cc |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-09T00:03:24Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-d1886f8e33b44c6dbe120ab7a3e030cc2023-12-12T15:00:30ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-12-011310.3389/fcimb.2023.12999771299977Gut microbiome: decision-makers in the microenvironment of colorectal cancerJingrun Han0Biao Zhang1Biao Zhang2Yongnian Zhang3Tianyi Yin4Yuying Cui5Yuying Cui6Yuying Cui7Jinming Liu8Yanfei Yang9Huiyi Song10Huiyi Song11Huiyi Song12Dong Shang13Dong Shang14Dong Shang15Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaLaboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartments of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaLaboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaInstitute (College) of Integrative Medicine, Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaLaboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaInstitute (College) of Integrative Medicine, Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaLaboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaInstitute (College) of Integrative Medicine, Dalian Medical University, Dalian, ChinaColorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for the second most common cause of gastrointestinal tumors. As one of the intestinal barriers, gut bacteria form biofilm, participate in intestinal work, and form the living environment of intestinal cells. Metagenomic next-generation sequencing (mNGS) of the gut bacteria in a large number of CRC patients has been established, enabling specific microbial signatures to be associated with colorectal adenomato-carcinoma. Gut bacteria are involved in both benign precursor lesions (polyps), in situ growth and metastasis of CRC. Therefore, the term tumorigenic bacteria was proposed in 2018, such as Escherichia coli, Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, etc. Meanwhile, bacteria toxins (such as cytolethal distending toxin (CDT), Colibactin (Clb), B. fragilis toxin) affect the tumor microenvironment and promote cancer occurrence and tumor immune escape. It is important to note that there are differences in the bacteria of different types of CRC. In this paper, the role of tumorigenic bacteria in the polyp-cancer transformation and the effects of their secreted toxins on the tumor microenvironment will be discussed, thereby further exploring new ideas for the prevention and treatment of CRC.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1299977/fullcolorectal cancergut bacteriatumor microbial microenvironmentimmune escapetherapy |
| spellingShingle | Jingrun Han Biao Zhang Biao Zhang Yongnian Zhang Tianyi Yin Yuying Cui Yuying Cui Yuying Cui Jinming Liu Yanfei Yang Huiyi Song Huiyi Song Huiyi Song Dong Shang Dong Shang Dong Shang Gut microbiome: decision-makers in the microenvironment of colorectal cancer Frontiers in Cellular and Infection Microbiology colorectal cancer gut bacteria tumor microbial microenvironment immune escape therapy |
| title | Gut microbiome: decision-makers in the microenvironment of colorectal cancer |
| title_full | Gut microbiome: decision-makers in the microenvironment of colorectal cancer |
| title_fullStr | Gut microbiome: decision-makers in the microenvironment of colorectal cancer |
| title_full_unstemmed | Gut microbiome: decision-makers in the microenvironment of colorectal cancer |
| title_short | Gut microbiome: decision-makers in the microenvironment of colorectal cancer |
| title_sort | gut microbiome decision makers in the microenvironment of colorectal cancer |
| topic | colorectal cancer gut bacteria tumor microbial microenvironment immune escape therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1299977/full |
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