Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances
Porcine circovirus type 2 (PCV2) infection can lead to porcine circovirus-associated disease (PCVAD), causing great economic losses to the global swine industry. Conventional vaccination programs are a major measure in the prevention and control of this disease. Currently, there are 5 commercially a...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/9/2005 |
| _version_ | 1797481380984127488 |
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| author | Jinshuo Guo Lei Hou Jianwei Zhou Dedong Wang Yongqiu Cui Xufei Feng Jue Liu |
| author_facet | Jinshuo Guo Lei Hou Jianwei Zhou Dedong Wang Yongqiu Cui Xufei Feng Jue Liu |
| author_sort | Jinshuo Guo |
| collection | DOAJ |
| description | Porcine circovirus type 2 (PCV2) infection can lead to porcine circovirus-associated disease (PCVAD), causing great economic losses to the global swine industry. Conventional vaccination programs are a major measure in the prevention and control of this disease. Currently, there are 5 commercially available PCV2 vaccines in the international market and 10 kinds commercially available PCV2 vaccines in the Chinese market that confer good efficacy against this virus by alleviating clinicopathological manifestations and enhancing growth performance in pigs. In addition, diverse experimental PCV2 vaccines with protective efficiency have been developed, including attenuated chimeric, nucleic acid, subunit, multivalent, and viral-vectored vaccines. These experimental vaccines have been shown to be relatively effective in improving the efficiency of pig production and simplifying prevention procedures. Adjuvants can be used to promote vaccines with higher protective immunity. Herein, we review the application of multiple commercial vaccines over the years and research advances in experimental vaccines, which provide the possibility for the development of superior vaccines to successfully prevent and control PCV2 infection in the future. |
| first_indexed | 2024-03-09T22:13:44Z |
| format | Article |
| id | doaj.art-d18b8231796e48529f7e8d1184609fd4 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T22:13:44Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d18b8231796e48529f7e8d1184609fd42023-11-23T19:27:55ZengMDPI AGViruses1999-49152022-09-01149200510.3390/v14092005Porcine Circovirus Type 2 Vaccines: Commercial Application and Research AdvancesJinshuo Guo0Lei Hou1Jianwei Zhou2Dedong Wang3Yongqiu Cui4Xufei Feng5Jue Liu6Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, ChinaPorcine circovirus type 2 (PCV2) infection can lead to porcine circovirus-associated disease (PCVAD), causing great economic losses to the global swine industry. Conventional vaccination programs are a major measure in the prevention and control of this disease. Currently, there are 5 commercially available PCV2 vaccines in the international market and 10 kinds commercially available PCV2 vaccines in the Chinese market that confer good efficacy against this virus by alleviating clinicopathological manifestations and enhancing growth performance in pigs. In addition, diverse experimental PCV2 vaccines with protective efficiency have been developed, including attenuated chimeric, nucleic acid, subunit, multivalent, and viral-vectored vaccines. These experimental vaccines have been shown to be relatively effective in improving the efficiency of pig production and simplifying prevention procedures. Adjuvants can be used to promote vaccines with higher protective immunity. Herein, we review the application of multiple commercial vaccines over the years and research advances in experimental vaccines, which provide the possibility for the development of superior vaccines to successfully prevent and control PCV2 infection in the future.https://www.mdpi.com/1999-4915/14/9/2005PCV2PCVADcommercial vaccinesexperimental vaccinesprotective efficiencyadjuvant |
| spellingShingle | Jinshuo Guo Lei Hou Jianwei Zhou Dedong Wang Yongqiu Cui Xufei Feng Jue Liu Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances Viruses PCV2 PCVAD commercial vaccines experimental vaccines protective efficiency adjuvant |
| title | Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances |
| title_full | Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances |
| title_fullStr | Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances |
| title_full_unstemmed | Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances |
| title_short | Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances |
| title_sort | porcine circovirus type 2 vaccines commercial application and research advances |
| topic | PCV2 PCVAD commercial vaccines experimental vaccines protective efficiency adjuvant |
| url | https://www.mdpi.com/1999-4915/14/9/2005 |
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