Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males.
Females outperform males on many social cognitive tasks. X-linked genes may contribute to this sex difference. Males possess one X chromosome, while females possess two X chromosomes. Functional variations in X-linked genes are therefore likely to impact more on males than females. Previous studies...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4481314?pdf=render |
| _version_ | 1818034774356262912 |
|---|---|
| author | Carla M Startin Chiara Fiorentini Michelle de Haan David H Skuse |
| author_facet | Carla M Startin Chiara Fiorentini Michelle de Haan David H Skuse |
| author_sort | Carla M Startin |
| collection | DOAJ |
| description | Females outperform males on many social cognitive tasks. X-linked genes may contribute to this sex difference. Males possess one X chromosome, while females possess two X chromosomes. Functional variations in X-linked genes are therefore likely to impact more on males than females. Previous studies of X-monosomic women with Turner syndrome suggest a genetic association with facial fear recognition abilities at Xp11.3, specifically at a single nucleotide polymorphism (SNP rs7055196) within the EFHC2 gene. Based on a strong hypothesis, we investigated an association between variation at SNP rs7055196 and facial fear recognition and theory of mind abilities in males. As predicted, males possessing the G allele had significantly poorer facial fear detection accuracy and theory of mind abilities than males possessing the A allele (with SNP variant accounting for up to 4.6% of variance). Variation in the X-linked EFHC2 gene at SNP rs7055196 is therefore associated with social cognitive abilities in males. |
| first_indexed | 2024-12-10T06:44:30Z |
| format | Article |
| id | doaj.art-d18c4c6c23874a86ae9644e57bec23d6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:44:30Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d18c4c6c23874a86ae9644e57bec23d62022-12-22T01:58:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013160410.1371/journal.pone.0131604Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males.Carla M StartinChiara FiorentiniMichelle de HaanDavid H SkuseFemales outperform males on many social cognitive tasks. X-linked genes may contribute to this sex difference. Males possess one X chromosome, while females possess two X chromosomes. Functional variations in X-linked genes are therefore likely to impact more on males than females. Previous studies of X-monosomic women with Turner syndrome suggest a genetic association with facial fear recognition abilities at Xp11.3, specifically at a single nucleotide polymorphism (SNP rs7055196) within the EFHC2 gene. Based on a strong hypothesis, we investigated an association between variation at SNP rs7055196 and facial fear recognition and theory of mind abilities in males. As predicted, males possessing the G allele had significantly poorer facial fear detection accuracy and theory of mind abilities than males possessing the A allele (with SNP variant accounting for up to 4.6% of variance). Variation in the X-linked EFHC2 gene at SNP rs7055196 is therefore associated with social cognitive abilities in males.http://europepmc.org/articles/PMC4481314?pdf=render |
| spellingShingle | Carla M Startin Chiara Fiorentini Michelle de Haan David H Skuse Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males. PLoS ONE |
| title | Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males. |
| title_full | Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males. |
| title_fullStr | Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males. |
| title_full_unstemmed | Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males. |
| title_short | Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males. |
| title_sort | variation in the x linked efhc2 gene is associated with social cognitive abilities in males |
| url | http://europepmc.org/articles/PMC4481314?pdf=render |
| work_keys_str_mv | AT carlamstartin variationinthexlinkedefhc2geneisassociatedwithsocialcognitiveabilitiesinmales AT chiarafiorentini variationinthexlinkedefhc2geneisassociatedwithsocialcognitiveabilitiesinmales AT michelledehaan variationinthexlinkedefhc2geneisassociatedwithsocialcognitiveabilitiesinmales AT davidhskuse variationinthexlinkedefhc2geneisassociatedwithsocialcognitiveabilitiesinmales |