Chromosome Folding Promotes Intrachromosomal Aberrations under Radiation- and Nuclease-Induced DNA Breakage

Chromosome Folding Promotes Intrachromosomal Aberrations under Radiation- and Nuclease-Induced DNA Breakage

The long-standing question in radiation and cancer biology is how principles of chromosome organization impact the formation of chromosomal aberrations (CAs). To address this issue, we developed a physical modeling approach and analyzed high-throughput genomic data from chromosome conformation captu...

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Bibliographic Details
Main Authors: Yuri Eidelman, Ilya Salnikov, Svetlana Slanina, Sergey Andreev
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
chromosomal aberrations
Hi-C
HTGTS
polymer modeling
3D chromosome organization
contact-first mechanism
Online Access:https://www.mdpi.com/1422-0067/22/22/12186

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