Synthesis, molecular docking study and anticancer activity of novel 1,3,4-oxadiazole derivatives as potential tubulin inhibitors

Synthesis, molecular docking study and anticancer activity of novel 1,3,4-oxadiazole derivatives as potential tubulin inhibitors

The current study reports on the synthesis and anticancer efficacy of novel oxadiazole derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies were used to confirm the newly produced compounds. In contrast to the conventional medicine colchicine, compounds 8e and 8f...

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Bibliographic Details
Main Authors:	Tarek A. Yousef, Abdulrahman G. Alhamzani, Mortaga M. Abou-Krisha, G. Kanthimathi, M.S. Raghu, K. Yogesh Kumar, M.K. Prashanth, Byong-Hun Jeon
Format:	Article
Language:	English
Published:	Elsevier 2023-02-01
Series:	Heliyon
Subjects:	1,3,4-Oxadiazole Anticancer Tubulin inhibitors Molecular docking
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844023006679

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