Modulation of AMPK/ TET2/ 5-hmC axis in response to metabolic alterations as a novel pathway for obesity-related colorectal cancer development
Abstract Obesity is a major risk factor for colorectal cancer (CRC). Sustained hyperglycemia destabilizes tumor suppressor ten-eleven translocation (TET) 2, which is a substrate of AMPK, thereby dysregulating 5-hydroxymethylcytosine (5-hmC). However, the role played by this novel pathway in the deve...
Main Authors: | Takashi Kon, Yu Sasaki, Yasuhiko Abe, Yusuke Onozato, Makoto Yagi, Naoko Mizumoto, Takayuki Sakai, Matsuki Umehara, Minami Ito, Shuhei Nakamura, Hiroki Goto, Yoshiyuki Ueno |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-02-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-29958-2 |
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