There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV
Some studies have suggested that human immunodeficiency virus (HIV) infection modifies the natural history of hepatitis C virus (HCV) infection, accelerating the progression of fibrosis and the development of cirrhosis. Our objective was to evaluate the fibrosis progression rate (FPR) in HCV/HIV-co-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2008-03-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300008 |
| _version_ | 1819274879913951232 |
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| author | A.R. Souza C.V. Tovo A.A. Mattos S. Chaves |
| author_facet | A.R. Souza C.V. Tovo A.A. Mattos S. Chaves |
| author_sort | A.R. Souza |
| collection | DOAJ |
| description | Some studies have suggested that human immunodeficiency virus (HIV) infection modifies the natural history of hepatitis C virus (HCV) infection, accelerating the progression of fibrosis and the development of cirrhosis. Our objective was to evaluate the fibrosis progression rate (FPR) in HCV/HIV-co-infected patients, and to identify factors that may influence it. HCV-mono-infected and HCV/HIV-co-infected patients with a known date of HCV infection (transfusion or injection drug use) and a liver biopsy were included. The FPR was defined as the ratio between the fibrosis stage (Metavir score) and the estimated length of infection in years and the result was reported as fibrosis units per year. The factors studied were gender, age at infection, consumption of alcohol, aminotransferase levels, histological activity grade, HCV genotype and viral load, CD4 cell count, HIV viral load, and the use of antiretroviral therapy. Sixty-five HCV-infected (group 1) and 53 HCV/HIV-co-infected (group 2) patients were evaluated over a period of 19 months. The mean FPR of groups 1 and 2 was 0.086 ± 0.074 and 0.109 ± 0.098 fibrosis units per year, respectively (P = 0.276). There was a correlation between length of HCV infection and stage of fibrosis in both groups. The age at infection, the aspartate aminotransferase level (r = 0.36) and the inflammatory activity grade were correlated with the FPR (P < 0.001). No difference in FPR was found between HCV-mono-infected and HCV/HIV-co-infected patients. |
| first_indexed | 2024-12-23T23:15:27Z |
| format | Article |
| id | doaj.art-d19050881ddb4b06b877d14c756db6fc |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-23T23:15:27Z |
| publishDate | 2008-03-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-d19050881ddb4b06b877d14c756db6fc2022-12-21T17:26:33ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2008-03-01413223228There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIVA.R. SouzaC.V. TovoA.A. MattosS. ChavesSome studies have suggested that human immunodeficiency virus (HIV) infection modifies the natural history of hepatitis C virus (HCV) infection, accelerating the progression of fibrosis and the development of cirrhosis. Our objective was to evaluate the fibrosis progression rate (FPR) in HCV/HIV-co-infected patients, and to identify factors that may influence it. HCV-mono-infected and HCV/HIV-co-infected patients with a known date of HCV infection (transfusion or injection drug use) and a liver biopsy were included. The FPR was defined as the ratio between the fibrosis stage (Metavir score) and the estimated length of infection in years and the result was reported as fibrosis units per year. The factors studied were gender, age at infection, consumption of alcohol, aminotransferase levels, histological activity grade, HCV genotype and viral load, CD4 cell count, HIV viral load, and the use of antiretroviral therapy. Sixty-five HCV-infected (group 1) and 53 HCV/HIV-co-infected (group 2) patients were evaluated over a period of 19 months. The mean FPR of groups 1 and 2 was 0.086 ± 0.074 and 0.109 ± 0.098 fibrosis units per year, respectively (P = 0.276). There was a correlation between length of HCV infection and stage of fibrosis in both groups. The age at infection, the aspartate aminotransferase level (r = 0.36) and the inflammatory activity grade were correlated with the FPR (P < 0.001). No difference in FPR was found between HCV-mono-infected and HCV/HIV-co-infected patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300008Hepatitis CHuman immunodeficiency virusHepatic fibrosisCirrhosis |
| spellingShingle | A.R. Souza C.V. Tovo A.A. Mattos S. Chaves There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV Brazilian Journal of Medical and Biological Research Hepatitis C Human immunodeficiency virus Hepatic fibrosis Cirrhosis |
| title | There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV |
| title_full | There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV |
| title_fullStr | There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV |
| title_full_unstemmed | There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV |
| title_short | There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV |
| title_sort | there is no difference in hepatic fibrosis rates of patients infected with hepatitis c virus and those co infected with hiv |
| topic | Hepatitis C Human immunodeficiency virus Hepatic fibrosis Cirrhosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300008 |
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