<it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extract
<p>Abstract</p> <p>Background</p> <p>Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities.</p> <p>Methods</p> <p&g...
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| Format: | Article |
| Language: | English |
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BMC
2012-07-01
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| Series: | BMC Complementary and Alternative Medicine |
| Online Access: | http://www.biomedcentral.com/1472-6882/12/104 |
| _version_ | 1828213989839994880 |
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| author | Aisha Abdalrahim F A Abu-Salah Khalid M Ismail Zhari Majid AminMalikShahAbdul |
| author_facet | Aisha Abdalrahim F A Abu-Salah Khalid M Ismail Zhari Majid AminMalikShahAbdul |
| author_sort | Aisha Abdalrahim F A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities.</p> <p>Methods</p> <p>A xanthones extract (81% α-mangostin and 16% γ-mangostin), was prepared by crystallization of a toluene extract of <it>G. mangostana</it> fruit rinds and was analyzed by LC-MS. Anti-colon cancer effect was investigated on HCT 116 human colorectal carcinoma cells including cytotoxicity, apoptosis, anti-tumorigenicity, and effect on cell signalling pathways. The <it>in vivo</it> anti-colon cancer activity was also investigated on subcutaneous tumors established in nude mice.</p> <p>Results</p> <p>The extract showed potent cytotoxicity (median inhibitory concentration 6.5 ± 1.0 μg/ml), due to induction of the mitochondrial pathway of apoptosis. Three key steps in tumor metastasis including the cell migration, cell invasion and clonogenicity, were also inhibited. The extract and α-mangostin up-regulate the MAPK/ERK, c-Myc/Max, and p53 cell signalling pathways. The xanthones extract, when fed to nude mice, caused significant growth inhibition of the subcutaneous tumor of HCT 116 colorectal carcinoma cells.</p> <p>Conclusions</p> <p>Our data suggest new mechanisms of action of α-mangostin and the <it>G. mangostana</it> xanthones, and suggest the xanthones extract of as a potential anti-colon cancer candidate.</p> |
| first_indexed | 2024-04-12T14:57:27Z |
| format | Article |
| id | doaj.art-d190d24130244895928555cd7bb9cbbe |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-04-12T14:57:27Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-d190d24130244895928555cd7bb9cbbe2022-12-22T03:28:11ZengBMCBMC Complementary and Alternative Medicine1472-68822012-07-0112110410.1186/1472-6882-12-104<it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extractAisha Abdalrahim F AAbu-Salah Khalid MIsmail ZhariMajid AminMalikShahAbdul<p>Abstract</p> <p>Background</p> <p>Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities.</p> <p>Methods</p> <p>A xanthones extract (81% α-mangostin and 16% γ-mangostin), was prepared by crystallization of a toluene extract of <it>G. mangostana</it> fruit rinds and was analyzed by LC-MS. Anti-colon cancer effect was investigated on HCT 116 human colorectal carcinoma cells including cytotoxicity, apoptosis, anti-tumorigenicity, and effect on cell signalling pathways. The <it>in vivo</it> anti-colon cancer activity was also investigated on subcutaneous tumors established in nude mice.</p> <p>Results</p> <p>The extract showed potent cytotoxicity (median inhibitory concentration 6.5 ± 1.0 μg/ml), due to induction of the mitochondrial pathway of apoptosis. Three key steps in tumor metastasis including the cell migration, cell invasion and clonogenicity, were also inhibited. The extract and α-mangostin up-regulate the MAPK/ERK, c-Myc/Max, and p53 cell signalling pathways. The xanthones extract, when fed to nude mice, caused significant growth inhibition of the subcutaneous tumor of HCT 116 colorectal carcinoma cells.</p> <p>Conclusions</p> <p>Our data suggest new mechanisms of action of α-mangostin and the <it>G. mangostana</it> xanthones, and suggest the xanthones extract of as a potential anti-colon cancer candidate.</p>http://www.biomedcentral.com/1472-6882/12/104 |
| spellingShingle | Aisha Abdalrahim F A Abu-Salah Khalid M Ismail Zhari Majid AminMalikShahAbdul <it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extract BMC Complementary and Alternative Medicine |
| title | <it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extract |
| title_full | <it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extract |
| title_fullStr | <it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extract |
| title_full_unstemmed | <it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extract |
| title_short | <it>In vitro and in vivo anti-colon cancer effects of Garcinia mangostana</it> xanthones extract |
| title_sort | it in vitro and in vivo anti colon cancer effects of garcinia mangostana it xanthones extract |
| url | http://www.biomedcentral.com/1472-6882/12/104 |
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