Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis
The pivotal regulatory role of non-coding RNAs (ncRNAs), especially exosomal ncRNAs, in ferroptosis significantly influences cancer cell fate. This review explores their involvement across various human cancers, focusing on microRNAs (miRNA), long non-coding RNAs (lncRNA), and circular RNAs (circRNA...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224001161 |
| _version_ | 1797291860375371776 |
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| author | Yiping Zhang Jun Xie |
| author_facet | Yiping Zhang Jun Xie |
| author_sort | Yiping Zhang |
| collection | DOAJ |
| description | The pivotal regulatory role of non-coding RNAs (ncRNAs), especially exosomal ncRNAs, in ferroptosis significantly influences cancer cell fate. This review explores their involvement across various human cancers, focusing on microRNAs (miRNA), long non-coding RNAs (lncRNA), and circular RNAs (circRNA). These ncRNAs either stimulate or inhibit ferroptosis by targeting key components, impacting cancer susceptibility to this form of cell death. Specific studies in lung, gastric, liver, cervical, bladder, pancreatic, and osteosarcoma cancers underscore the crucial role of exosomal ncRNAs in modulating ferroptosis, influencing cancer progression, and therapeutic responses. Emphasizing the therapeutic potential of exosomal ncRNAs, we discuss their ability to deliver circRNA, miRNA, and lncRNA to target cells. Despite being in early stages with challenges in bioengineering for drug delivery, these studies hold promise for future clinical applications. Noteworthy findings include inhibiting exosome production to overcome ferroptosis resistance in lung adenocarcinoma and the potential of exosomal DACT3-AS1 to sensitize gastric cancer cells to ferroptosis. The review concludes by highlighting exosomal ncRNAs like miR-4443 and miR-660–5p as promising therapeutic targets, offering avenues for precise cancer interventions by modulating signaling pathways and sensitizing cells to ferroptosis. Overall, this review enhances our understanding of cancer pathogenesis and presents new horizons for targeted therapeutic interventions, revealing the intricate interplay between exosomal ncRNAs and ferroptosis. |
| first_indexed | 2024-03-07T19:43:51Z |
| format | Article |
| id | doaj.art-d1912c12e01d43039400e75f8ae75c3f |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-07T19:43:51Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-d1912c12e01d43039400e75f8ae75c3f2024-02-29T05:17:50ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-03-01172116235Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesisYiping Zhang0Jun Xie1School of Life Sciences, Fudan University, Shanghai 200438, China; Wanchuanhui (Shanghai) Medical Technology Co., Ltd, Shanghai 201501, ChinaSchool of Life Sciences, Fudan University, Shanghai 200438, China; Wanchuanhui (Shanghai) Medical Technology Co., Ltd, Shanghai 201501, China; Corresponding author at: School of Life Sciences, Fudan University, Shanghai 200438, China.The pivotal regulatory role of non-coding RNAs (ncRNAs), especially exosomal ncRNAs, in ferroptosis significantly influences cancer cell fate. This review explores their involvement across various human cancers, focusing on microRNAs (miRNA), long non-coding RNAs (lncRNA), and circular RNAs (circRNA). These ncRNAs either stimulate or inhibit ferroptosis by targeting key components, impacting cancer susceptibility to this form of cell death. Specific studies in lung, gastric, liver, cervical, bladder, pancreatic, and osteosarcoma cancers underscore the crucial role of exosomal ncRNAs in modulating ferroptosis, influencing cancer progression, and therapeutic responses. Emphasizing the therapeutic potential of exosomal ncRNAs, we discuss their ability to deliver circRNA, miRNA, and lncRNA to target cells. Despite being in early stages with challenges in bioengineering for drug delivery, these studies hold promise for future clinical applications. Noteworthy findings include inhibiting exosome production to overcome ferroptosis resistance in lung adenocarcinoma and the potential of exosomal DACT3-AS1 to sensitize gastric cancer cells to ferroptosis. The review concludes by highlighting exosomal ncRNAs like miR-4443 and miR-660–5p as promising therapeutic targets, offering avenues for precise cancer interventions by modulating signaling pathways and sensitizing cells to ferroptosis. Overall, this review enhances our understanding of cancer pathogenesis and presents new horizons for targeted therapeutic interventions, revealing the intricate interplay between exosomal ncRNAs and ferroptosis.http://www.sciencedirect.com/science/article/pii/S0753332224001161Non-coding RNAsExosomesFerroptosisCancer |
| spellingShingle | Yiping Zhang Jun Xie Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis Biomedicine & Pharmacotherapy Non-coding RNAs Exosomes Ferroptosis Cancer |
| title | Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis |
| title_full | Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis |
| title_fullStr | Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis |
| title_full_unstemmed | Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis |
| title_short | Unveiling the role of ferroptosis-associated exosomal non-coding RNAs in cancer pathogenesis |
| title_sort | unveiling the role of ferroptosis associated exosomal non coding rnas in cancer pathogenesis |
| topic | Non-coding RNAs Exosomes Ferroptosis Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224001161 |
| work_keys_str_mv | AT yipingzhang unveilingtheroleofferroptosisassociatedexosomalnoncodingrnasincancerpathogenesis AT junxie unveilingtheroleofferroptosisassociatedexosomalnoncodingrnasincancerpathogenesis |