Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis. To understand how exosomes might contribute to cell transformation, we utilized the classic two-step NIH/3T3 cell transformatio...

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Bibliographic Details
Main Authors: Karoliina Stefanius, Kelly Servage, Marcela de Souza Santos, Hillery Fields Gray, Jason E Toombs, Suneeta Chimalapati, Min S Kim, Venkat S Malladi, Rolf Brekken, Kim Orth
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
exosomes
transformation
cancer
pancreatic cancer
proteomics
Online Access:https://elifesciences.org/articles/40226

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