Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway

Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway

Background/Aims: Puerarin shows a wide range of biological activities, including affecting the cardiac differentiation from murine embryonic stem (mES) cells. However, little is known about its effect and mechanism of action on the self-renewal of mES cells. This study aimed to determine the effect...

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Bibliographic Details
Main Authors: Mengmeng Yin, Yin Yuan, Yurong Cui, Xian Hong, Hongyan Luo, Xinwu Hu, Ming Tang, Jurgen Hescheler, Jiaoya Xi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Puerarin
Murine embryonic stem cells
Self-renewal
REST
MiR-21
Online Access:http://www.karger.com/Article/FullText/430374

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