Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review
ABSTRACT The recognition of Cerebrovascular Disease (CVD) at earlier clinical stages may favor the control of vascular risk factors and prevention of dementia. However, operational criteria for symptomatic phases at non-dementia stages are often difficult, as the current criteria normally require th...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Neurologia Cognitiva e do Comportamento
|
| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000400394&lng=en&tlng=en |
| _version_ | 1818490152666791936 |
|---|---|
| author | Felipe Kenji Sudo Gilberto Sousa Alves Chan Tiel Letice Ericeira-Valente Denise Madeira Moreira Jerson Laks Eliasz Engelhardt |
| author_facet | Felipe Kenji Sudo Gilberto Sousa Alves Chan Tiel Letice Ericeira-Valente Denise Madeira Moreira Jerson Laks Eliasz Engelhardt |
| author_sort | Felipe Kenji Sudo |
| collection | DOAJ |
| description | ABSTRACT The recognition of Cerebrovascular Disease (CVD) at earlier clinical stages may favor the control of vascular risk factors and prevention of dementia. However, operational criteria for symptomatic phases at non-dementia stages are often difficult, as the current criteria normally require the evidence of extensive subcortical disease. OBJECTIVE To identify the neuroimaging profile of Vascular Mild Cognitive Impairment (VaMCI), the impact of those aspects over cognition and the neuropsychological tests that distinguished VaMCI from other groups. METHODS Searches were performed in Scopus, ISI and PsycINFO, using the following key terms: "vascular mild cognitive impairment" OR "vascular cognitive impairment no dementia" OR "vascular cognitive impairment not demented" OR "subcortical mild cognitive impairment". RESULTS Of 249 papers, 20 studies were selected. Ten of those included only patients with severe White Matter Hyperintensities (WMH), whereas 10 others admitted subjects with moderate-to-severe WMH. Both groups showed poor performances in Executive Function (EF) tasks in comparison to normal controls and other diagnostic groups. Among EF tests, those assessing "complex" EF abilities consistently distinguished VaMCI from other groups, regardless of the severity of WMH. VaMCI subjects with severe or moderate-to-severe WMH showed cognitive deficits in comparison with other groups. "Complex" EF tests were the most useful in differentiating those patients from the other groups. CONCLUSION The occurrence of VaMCI may be associated with the presence of CVD at moderate levels; the detection of vascular damage at earlier stages may allow the adoption of therapeutic actions with significant effect-sizes. |
| first_indexed | 2024-12-10T17:13:22Z |
| format | Article |
| id | doaj.art-d1936045f228443f83497ef63f8bc27e |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-12-10T17:13:22Z |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-d1936045f228443f83497ef63f8bc27e2022-12-22T01:40:15ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57649439440410.1590/1980-57642015DN94000394S1980-57642015000400394Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic reviewFelipe Kenji SudoGilberto Sousa AlvesChan TielLetice Ericeira-ValenteDenise Madeira MoreiraJerson LaksEliasz EngelhardtABSTRACT The recognition of Cerebrovascular Disease (CVD) at earlier clinical stages may favor the control of vascular risk factors and prevention of dementia. However, operational criteria for symptomatic phases at non-dementia stages are often difficult, as the current criteria normally require the evidence of extensive subcortical disease. OBJECTIVE To identify the neuroimaging profile of Vascular Mild Cognitive Impairment (VaMCI), the impact of those aspects over cognition and the neuropsychological tests that distinguished VaMCI from other groups. METHODS Searches were performed in Scopus, ISI and PsycINFO, using the following key terms: "vascular mild cognitive impairment" OR "vascular cognitive impairment no dementia" OR "vascular cognitive impairment not demented" OR "subcortical mild cognitive impairment". RESULTS Of 249 papers, 20 studies were selected. Ten of those included only patients with severe White Matter Hyperintensities (WMH), whereas 10 others admitted subjects with moderate-to-severe WMH. Both groups showed poor performances in Executive Function (EF) tasks in comparison to normal controls and other diagnostic groups. Among EF tests, those assessing "complex" EF abilities consistently distinguished VaMCI from other groups, regardless of the severity of WMH. VaMCI subjects with severe or moderate-to-severe WMH showed cognitive deficits in comparison with other groups. "Complex" EF tests were the most useful in differentiating those patients from the other groups. CONCLUSION The occurrence of VaMCI may be associated with the presence of CVD at moderate levels; the detection of vascular damage at earlier stages may allow the adoption of therapeutic actions with significant effect-sizes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000400394&lng=en&tlng=encerebrovascular disordersvascular dementiacerebral infarctionneurological diagnostic techniques |
| spellingShingle | Felipe Kenji Sudo Gilberto Sousa Alves Chan Tiel Letice Ericeira-Valente Denise Madeira Moreira Jerson Laks Eliasz Engelhardt Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review Dementia & Neuropsychologia cerebrovascular disorders vascular dementia cerebral infarction neurological diagnostic techniques |
| title | Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review |
| title_full | Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review |
| title_fullStr | Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review |
| title_full_unstemmed | Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review |
| title_short | Neuroimaging criteria and cognitive performance in vascular mild cognitive impairment: a systematic review |
| title_sort | neuroimaging criteria and cognitive performance in vascular mild cognitive impairment a systematic review |
| topic | cerebrovascular disorders vascular dementia cerebral infarction neurological diagnostic techniques |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000400394&lng=en&tlng=en |
| work_keys_str_mv | AT felipekenjisudo neuroimagingcriteriaandcognitiveperformanceinvascularmildcognitiveimpairmentasystematicreview AT gilbertosousaalves neuroimagingcriteriaandcognitiveperformanceinvascularmildcognitiveimpairmentasystematicreview AT chantiel neuroimagingcriteriaandcognitiveperformanceinvascularmildcognitiveimpairmentasystematicreview AT leticeericeiravalente neuroimagingcriteriaandcognitiveperformanceinvascularmildcognitiveimpairmentasystematicreview AT denisemadeiramoreira neuroimagingcriteriaandcognitiveperformanceinvascularmildcognitiveimpairmentasystematicreview AT jersonlaks neuroimagingcriteriaandcognitiveperformanceinvascularmildcognitiveimpairmentasystematicreview AT eliaszengelhardt neuroimagingcriteriaandcognitiveperformanceinvascularmildcognitiveimpairmentasystematicreview |