Hepatitis C Virus Induces the Ubiquitin-Editing Enzyme A20 via Depletion of the Transcription Factor Upstream Stimulatory Factor 1 To Support Its Replication

Hepatitis C Virus Induces the Ubiquitin-Editing Enzyme A20 via Depletion of the Transcription Factor Upstream Stimulatory Factor 1 To Support Its Replication

ABSTRACT Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), also known as A20, is a ubiquitin-editing enzyme capable of ubiquitination or deubiquitination of its target proteins. In this study, we show that hepatitis C virus (HCV) infection could induce the expression of A20 via the activation...

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Bibliographic Details
Main Authors: Jiyoung Lee, Stephanie T. Chan, Ja Yeon Kim, Jing-hsiung James Ou
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
A20 ubiquitin enzyme
HCV IRES
USF-1 transcription factor
hepatitis C virus
Online Access:https://journals.asm.org/doi/10.1128/mBio.01660-19

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