Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study
Background: This study aimed to evaluate the predicting factors affecting sperm retrieval. We prospectively assessedthe relationship between sonographic and microdissection testicular sperm extraction (mTESE) findings in Klinefeltersyndrome (KS).Materials and Methods: In this prospective study, 44 a...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2023-10-01
|
| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | https://www.ijfs.ir/article_705641_9e2e91c1abb5548fd3d8d13b76c89c86.pdf |
| _version_ | 1797743747102932992 |
|---|---|
| author | Fereshteh Aliakbari Neda Taghizabet Fatemeh Rezaei-Tazangi Hamid Kalantari Ahmad Vosough Dizaj Maryam Mohammadi Hesamoddin Sajadi Mohammad Ali Sadighi Gilani |
| author_facet | Fereshteh Aliakbari Neda Taghizabet Fatemeh Rezaei-Tazangi Hamid Kalantari Ahmad Vosough Dizaj Maryam Mohammadi Hesamoddin Sajadi Mohammad Ali Sadighi Gilani |
| author_sort | Fereshteh Aliakbari |
| collection | DOAJ |
| description | Background: This study aimed to evaluate the predicting factors affecting sperm retrieval. We prospectively assessedthe relationship between sonographic and microdissection testicular sperm extraction (mTESE) findings in Klinefeltersyndrome (KS).Materials and Methods: In this prospective study, 44 azoospermic men with 47, XXY karyotypes participated in thisstudy. In order to evaluate the amount of blood supply in different parts of testicular tissue, a doppler ultra-sonographicwas performed. Also, for the detection of sperm in this group mTESE technique was performed.Results: The age average of positive mTESE and negative mTESE groups was 29.4 and 33.6 years, respectively. Bycomparing the testicle volume (based on the data obtained from the clinical examinations conducted by the urologist)it was determined that there is no significant difference between mTESE positive and negative groups. Folliclestimulatinghormone (FSH) levels in men with negative mTESE (P=0.03) and testosterone levels in men with positivemTESE significantly increased (P=0.017). The overall rate of testis vascularity was significantly higher in the positivemTESE group than in the negative mTESE group. The clinical pregnancy rate in positive mTESE men was 9% percycle, 16.6% per embryos were transferred (ET), and 12.5% per cycle.Conclusion: Totally, our observation indicated that there is not a significant relationship between sonographic and mTESEresults in KS patients. However, more investigations with bigger sample Size can be useful to validate our results. |
| first_indexed | 2024-03-12T14:59:52Z |
| format | Article |
| id | doaj.art-d195c15bb4f249c08c3538be4b8685f1 |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-03-12T14:59:52Z |
| publishDate | 2023-10-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-d195c15bb4f249c08c3538be4b8685f12023-08-14T09:37:54ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782023-10-0117427628010.22074/ijfs.2023.562534.1371705641Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective StudyFereshteh Aliakbari0Neda Taghizabet1Fatemeh Rezaei-Tazangi2Hamid Kalantari3Ahmad Vosough Dizaj4Maryam Mohammadi5Hesamoddin Sajadi6Mohammad Ali Sadighi Gilani7Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranReproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranBackground: This study aimed to evaluate the predicting factors affecting sperm retrieval. We prospectively assessedthe relationship between sonographic and microdissection testicular sperm extraction (mTESE) findings in Klinefeltersyndrome (KS).Materials and Methods: In this prospective study, 44 azoospermic men with 47, XXY karyotypes participated in thisstudy. In order to evaluate the amount of blood supply in different parts of testicular tissue, a doppler ultra-sonographicwas performed. Also, for the detection of sperm in this group mTESE technique was performed.Results: The age average of positive mTESE and negative mTESE groups was 29.4 and 33.6 years, respectively. Bycomparing the testicle volume (based on the data obtained from the clinical examinations conducted by the urologist)it was determined that there is no significant difference between mTESE positive and negative groups. Folliclestimulatinghormone (FSH) levels in men with negative mTESE (P=0.03) and testosterone levels in men with positivemTESE significantly increased (P=0.017). The overall rate of testis vascularity was significantly higher in the positivemTESE group than in the negative mTESE group. The clinical pregnancy rate in positive mTESE men was 9% percycle, 16.6% per embryos were transferred (ET), and 12.5% per cycle.Conclusion: Totally, our observation indicated that there is not a significant relationship between sonographic and mTESEresults in KS patients. However, more investigations with bigger sample Size can be useful to validate our results.https://www.ijfs.ir/article_705641_9e2e91c1abb5548fd3d8d13b76c89c86.pdfazoospermicklinefeltertesticular sperm extractionultrasonography |
| spellingShingle | Fereshteh Aliakbari Neda Taghizabet Fatemeh Rezaei-Tazangi Hamid Kalantari Ahmad Vosough Dizaj Maryam Mohammadi Hesamoddin Sajadi Mohammad Ali Sadighi Gilani Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study International Journal of Fertility and Sterility azoospermic klinefelter testicular sperm extraction ultrasonography |
| title | Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study |
| title_full | Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study |
| title_fullStr | Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study |
| title_full_unstemmed | Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study |
| title_short | Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study |
| title_sort | evaluation of predicting factors affecting sperm retrieval in patients with klinefelter syndrome a prospective study |
| topic | azoospermic klinefelter testicular sperm extraction ultrasonography |
| url | https://www.ijfs.ir/article_705641_9e2e91c1abb5548fd3d8d13b76c89c86.pdf |
| work_keys_str_mv | AT fereshtehaliakbari evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy AT nedataghizabet evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy AT fatemehrezaeitazangi evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy AT hamidkalantari evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy AT ahmadvosoughdizaj evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy AT maryammohammadi evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy AT hesamoddinsajadi evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy AT mohammadalisadighigilani evaluationofpredictingfactorsaffectingspermretrievalinpatientswithklinefeltersyndromeaprospectivestudy |