Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle
Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhib...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Veterinary World
2019-05-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.veterinaryworld.org/Vol.12/May-2019/9.pdf |
| _version_ | 1819126156519014400 |
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| author | Bambang Purwanto Sundari Indah Wiyasihati Putri Ayu Masyitha Kristanti Wanito Wigati Irfiansyah Irwadi |
| author_facet | Bambang Purwanto Sundari Indah Wiyasihati Putri Ayu Masyitha Kristanti Wanito Wigati Irfiansyah Irwadi |
| author_sort | Bambang Purwanto |
| collection | DOAJ |
| description | Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity.
Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse.
Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days.
Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse.
Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting. |
| first_indexed | 2024-12-22T07:51:33Z |
| format | Article |
| id | doaj.art-d195c197aea543f0b4fbdfc499af999a |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-22T07:51:33Z |
| publishDate | 2019-05-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-d195c197aea543f0b4fbdfc499af999a2022-12-21T18:33:28ZengVeterinary WorldVeterinary World0972-89882231-09162019-05-0112568468810.14202/vetworld.2019.684-688Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscleBambang Purwanto0Sundari Indah Wiyasihati1Putri Ayu Masyitha2Kristanti Wanito Wigati3Irfiansyah Irwadi4Department of Physiology, Faculty of Medicine, Universitas Airlangga, Indonesia.Department of Physiology, Faculty of Medicine, Universitas Airlangga, Indonesia.School of Medicine, Faculty of Medicine, Universitas Airlangga, Indonesia.Department of Physiology, Faculty of Medicine, Universitas Airlangga, Indonesia.Department of Physiology, Faculty of Medicine, Universitas Airlangga, Indonesia.Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity. Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse. Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days. Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse. Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.http://www.veterinaryworld.org/Vol.12/May-2019/9.pdfdiabetesglucose transporterinterleukinmuscle |
| spellingShingle | Bambang Purwanto Sundari Indah Wiyasihati Putri Ayu Masyitha Kristanti Wanito Wigati Irfiansyah Irwadi Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle Veterinary World diabetes glucose transporter interleukin muscle |
| title | Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle |
| title_full | Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle |
| title_fullStr | Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle |
| title_full_unstemmed | Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle |
| title_short | Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle |
| title_sort | golden sea cucumber extract revives glucose transporter 4 and interleukin 6 protein level in diabetic mouse muscle |
| topic | diabetes glucose transporter interleukin muscle |
| url | http://www.veterinaryworld.org/Vol.12/May-2019/9.pdf |
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