Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two endocannabinoid-activated G-protein-coupled receptors

Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two endocannabinoid-activated G-protein-coupled receptors

Cannabidiol (CBD), the major non-psychoactive phytocannabinoid present in the plant Cannabis sativa, has displayed beneficial pharmacological effects in the treatment of several neurological disorders including, epilepsy, Parkinson’s disease, and Alzheimer’s disease. In particular, CBD is able to mo...

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Bibliographic Details
Main Authors: Eliud Morales Dávila, Felipe Patricio, Mariana Rebolledo-Bustillo, David Garcia-Gomez, Juan Carlos Garcia Hernandez, Brenda L. Sanchez-Gaytan, Ilhuicamina Daniel Limón, Jose Manuel Perez-Aguilar
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
cannabidiol
G-protein-coupled receptors
all-atom molecular dynamic simulations
G-protein-coupled receptor 55
cannabinoid type-1 receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.945935/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.945935/full

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