From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization
Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and lar...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-02-01
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| Series: | Antibodies |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4468/3/1/130 |
| _version_ | 1819012661999828992 |
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| author | Antoine Prigent Nicolas Maillard Léna Absi Chaker Aloui Fabrice Cognasse Sandrine Laradi Christophe Mariat Olivier Garraud |
| author_facet | Antoine Prigent Nicolas Maillard Léna Absi Chaker Aloui Fabrice Cognasse Sandrine Laradi Christophe Mariat Olivier Garraud |
| author_sort | Antoine Prigent |
| collection | DOAJ |
| description | Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses. |
| first_indexed | 2024-12-21T01:47:36Z |
| format | Article |
| id | doaj.art-d19ab0dd67ad43748d3c3635d2d83212 |
| institution | Directory Open Access Journal |
| issn | 2073-4468 |
| language | English |
| last_indexed | 2024-12-21T01:47:36Z |
| publishDate | 2014-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj.art-d19ab0dd67ad43748d3c3635d2d832122022-12-21T19:19:59ZengMDPI AGAntibodies2073-44682014-02-013113015210.3390/antib3010130antib3010130From Donor to Recipient: Current Questions Relating to Humoral AlloimmunizationAntoine Prigent0Nicolas Maillard1Léna Absi2Chaker Aloui3Fabrice Cognasse4Sandrine Laradi5Christophe Mariat6Olivier Garraud7GIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceEFS Auvergne-Loire, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceAlloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.http://www.mdpi.com/2073-4468/3/1/130transfusiontransplantationalloimmunizationtoleranceHLA |
| spellingShingle | Antoine Prigent Nicolas Maillard Léna Absi Chaker Aloui Fabrice Cognasse Sandrine Laradi Christophe Mariat Olivier Garraud From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization Antibodies transfusion transplantation alloimmunization tolerance HLA |
| title | From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization |
| title_full | From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization |
| title_fullStr | From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization |
| title_full_unstemmed | From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization |
| title_short | From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization |
| title_sort | from donor to recipient current questions relating to humoral alloimmunization |
| topic | transfusion transplantation alloimmunization tolerance HLA |
| url | http://www.mdpi.com/2073-4468/3/1/130 |
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