Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies
Abstract Background The oxidative balance score (OBS) has been utilized to assess the overall pro- and antioxidant exposure status in various chronic diseases. The current meta-analysis was carried out to pool the association between OBS and the risk of cancer. Methods We systematically searched the...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11657-w |
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| author | Motahareh Hasani Seyedeh Parisa Alinia Maryam Khazdouz Sahar Sobhani Parham Mardi Hanieh-Sadat Ejtahed Mostafa Qorbani |
| author_facet | Motahareh Hasani Seyedeh Parisa Alinia Maryam Khazdouz Sahar Sobhani Parham Mardi Hanieh-Sadat Ejtahed Mostafa Qorbani |
| author_sort | Motahareh Hasani |
| collection | DOAJ |
| description | Abstract Background The oxidative balance score (OBS) has been utilized to assess the overall pro- and antioxidant exposure status in various chronic diseases. The current meta-analysis was carried out to pool the association between OBS and the risk of cancer. Methods We systematically searched the Web of Science, PubMed, Scopus, Embase, and Google Scholar up to August 2023. All observational studies which evaluated the association of OBS with the risk of cancers were included. There was no time of publication or language restrictions. Heterogeneity between studies was assessed using the Chi-square-based Q-test and the I2. A random-effects model meta-analysis was conducted to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by subgroup and meta-regression analysis. Results Totally, 15 studies (9 case–control and 6 cohorts) were eligible for meta-analysis. Random effect model meta-analysis of case–control studies showed that higher OBS significantly decreases the odds of cancers (pooled OR: 0.64, 95% CI: 0.54, 0.74). In the cohort studies, the association of OBS with the risk of cancers was not significant (pooled HR: 0.97, 95% CI: 0.80,1.18). The subgroup analysis showed that cancer type and gender were the potential sources of heterogeneity. Conclusion Our results show an inverse and significant association between higher OBS and odds of colorectal cancers in case–control and cohort studies. In the case of prostate cancer in cohort studies, our results did not align with the hypothesis. Considering the importance of diet and antioxidant balance in the conditions of malignancy, it is suggested to conduct more comprehensive studies with standard measurement methods to obtain conclusive results. |
| first_indexed | 2024-03-09T15:07:03Z |
| format | Article |
| id | doaj.art-d19adaee9406467b9343eaad34560638 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-09T15:07:03Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-d19adaee9406467b9343eaad345606382023-11-26T13:36:35ZengBMCBMC Cancer1471-24072023-11-0123111810.1186/s12885-023-11657-wOxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studiesMotahareh Hasani0Seyedeh Parisa Alinia1Maryam Khazdouz2Sahar Sobhani3Parham Mardi4Hanieh-Sadat Ejtahed5Mostafa Qorbani6Department of Nutrition, School of Public Health, Golestan University of Medical SciencesStudent Research Committee , Alborz University of Medical SciencesGrowth and Development Research Center, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Alborz University of Medical SciencesNon-Communicable Diseases Research Center, Alborz University of Medical SciencesObesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Alborz University of Medical SciencesAbstract Background The oxidative balance score (OBS) has been utilized to assess the overall pro- and antioxidant exposure status in various chronic diseases. The current meta-analysis was carried out to pool the association between OBS and the risk of cancer. Methods We systematically searched the Web of Science, PubMed, Scopus, Embase, and Google Scholar up to August 2023. All observational studies which evaluated the association of OBS with the risk of cancers were included. There was no time of publication or language restrictions. Heterogeneity between studies was assessed using the Chi-square-based Q-test and the I2. A random-effects model meta-analysis was conducted to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by subgroup and meta-regression analysis. Results Totally, 15 studies (9 case–control and 6 cohorts) were eligible for meta-analysis. Random effect model meta-analysis of case–control studies showed that higher OBS significantly decreases the odds of cancers (pooled OR: 0.64, 95% CI: 0.54, 0.74). In the cohort studies, the association of OBS with the risk of cancers was not significant (pooled HR: 0.97, 95% CI: 0.80,1.18). The subgroup analysis showed that cancer type and gender were the potential sources of heterogeneity. Conclusion Our results show an inverse and significant association between higher OBS and odds of colorectal cancers in case–control and cohort studies. In the case of prostate cancer in cohort studies, our results did not align with the hypothesis. Considering the importance of diet and antioxidant balance in the conditions of malignancy, it is suggested to conduct more comprehensive studies with standard measurement methods to obtain conclusive results.https://doi.org/10.1186/s12885-023-11657-wOxidative balance scoreCancerMalignancyNeoplasms |
| spellingShingle | Motahareh Hasani Seyedeh Parisa Alinia Maryam Khazdouz Sahar Sobhani Parham Mardi Hanieh-Sadat Ejtahed Mostafa Qorbani Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies BMC Cancer Oxidative balance score Cancer Malignancy Neoplasms |
| title | Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies |
| title_full | Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies |
| title_fullStr | Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies |
| title_short | Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies |
| title_sort | oxidative balance score and risk of cancer a systematic review and meta analysis of observational studies |
| topic | Oxidative balance score Cancer Malignancy Neoplasms |
| url | https://doi.org/10.1186/s12885-023-11657-w |
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