Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection

Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection

Tuberculosis remains a leading cause of death globally despite curative treatment, partly due to the difficulty of identifying patients who will not respond to therapy. Simple host biomarkers that correlate with response to drug treatment would facilitate improvement in outcomes and the evaluation o...

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Bibliographic Details
Main Authors: Lerato N. Ndlovu, Lauren Peetluk, Sashen Moodley, Shepherd Nhamoyebonde, Abigail T. Ngoepe, Matilda Mazibuko, Khadija Khan, Farina Karim, Alexander S. Pym, Fernanda Maruri, Mahomed-Yunus S. Moosa, Yuri F. van der Heijden, Timothy R. Sterling, Alasdair Leslie
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
tuberculosis biomarker
neutrophil phenotype
blood neutrophil count
tuberculosis treatment outcome
tuberculosis disease severity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01872/full

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