Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population
Subclinical atherosclerosis (SA) is the presence of coronary calcification in the absence of cardiovascular symptoms, and it usually progresses to atherosclerotic disease. Studies have shown an association of osteoprotegerin gene (<i>OPG</i>) variants with calcification process in cardio...
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MDPI AG
2022-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1433 |
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| author | Benny Giovanni Cazarín-Santos Nonanzit Pérez-Hernández Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Óscar Pérez-Méndez Juan Rodríguez-Silverio Bladimir Roque-Ramírez Verónica Marusa Borgonio-Cuadra José Manuel Rodríguez-Pérez |
| author_facet | Benny Giovanni Cazarín-Santos Nonanzit Pérez-Hernández Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Óscar Pérez-Méndez Juan Rodríguez-Silverio Bladimir Roque-Ramírez Verónica Marusa Borgonio-Cuadra José Manuel Rodríguez-Pérez |
| author_sort | Benny Giovanni Cazarín-Santos |
| collection | DOAJ |
| description | Subclinical atherosclerosis (SA) is the presence of coronary calcification in the absence of cardiovascular symptoms, and it usually progresses to atherosclerotic disease. Studies have shown an association of osteoprotegerin gene (<i>OPG</i>) variants with calcification process in cardiovascular diseases; however, to this day there are no studies that evaluate individuals in the asymptomatic stage of atherosclerotic disease. Therefore, the purpose of this study was to analyze the association of four genetic variants and haplotypes of the <i>OPG</i> gene with the development of SA, through TaqMan genotyping assays. We also aimed to identify potential response elements for transcription factors in these genetic variants. The study included 1413 asymptomatic participants (1041 were controls and 372 were individuals with SA). The rs3102735 polymorphism appeared as a protective marker (OR = 0.693; 95% CI = 0.493–0.974; <i>p</i><sub>heterozygote</sub> = 0.035; OR = 0.699; 95% CI = 0.496–0.985; <i>p</i><sub>codominant</sub> <sub>1</sub> = 0.040) and two haplotypes were associated with SA, one as a decreased risk: <i>GACC</i> (OR = 0.641, 95% CI = 0.414–0.990, <i>p</i> = 0.045) and another as an increased risk: <i>GACT</i> (OR = 1.208, 95% CI = 1.020–1.431, <i>p</i> = 0.029). Our data suggest a lower risk of SA in rs3102735 <i>C</i> carriers in a representative sample of Mexican mestizo population. |
| first_indexed | 2024-03-10T00:00:46Z |
| format | Article |
| id | doaj.art-d19f63ff6e544752bed5625d768e4a6f |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:00:46Z |
| publishDate | 2022-06-01 |
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| series | Diagnostics |
| spelling | doaj.art-d19f63ff6e544752bed5625d768e4a6f2023-11-23T16:18:07ZengMDPI AGDiagnostics2075-44182022-06-01126143310.3390/diagnostics12061433Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo PopulationBenny Giovanni Cazarín-Santos0Nonanzit Pérez-Hernández1Rosalinda Posadas-Sánchez2Gilberto Vargas-Alarcón3Óscar Pérez-Méndez4Juan Rodríguez-Silverio5Bladimir Roque-Ramírez6Verónica Marusa Borgonio-Cuadra7José Manuel Rodríguez-Pérez8Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoLaboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, MexicoDepartamento de Medicina Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoSubclinical atherosclerosis (SA) is the presence of coronary calcification in the absence of cardiovascular symptoms, and it usually progresses to atherosclerotic disease. Studies have shown an association of osteoprotegerin gene (<i>OPG</i>) variants with calcification process in cardiovascular diseases; however, to this day there are no studies that evaluate individuals in the asymptomatic stage of atherosclerotic disease. Therefore, the purpose of this study was to analyze the association of four genetic variants and haplotypes of the <i>OPG</i> gene with the development of SA, through TaqMan genotyping assays. We also aimed to identify potential response elements for transcription factors in these genetic variants. The study included 1413 asymptomatic participants (1041 were controls and 372 were individuals with SA). The rs3102735 polymorphism appeared as a protective marker (OR = 0.693; 95% CI = 0.493–0.974; <i>p</i><sub>heterozygote</sub> = 0.035; OR = 0.699; 95% CI = 0.496–0.985; <i>p</i><sub>codominant</sub> <sub>1</sub> = 0.040) and two haplotypes were associated with SA, one as a decreased risk: <i>GACC</i> (OR = 0.641, 95% CI = 0.414–0.990, <i>p</i> = 0.045) and another as an increased risk: <i>GACT</i> (OR = 1.208, 95% CI = 1.020–1.431, <i>p</i> = 0.029). Our data suggest a lower risk of SA in rs3102735 <i>C</i> carriers in a representative sample of Mexican mestizo population.https://www.mdpi.com/2075-4418/12/6/1433osteoprotegerinsubclinical atherosclerosisgenetic susceptibilitysingle nucleotide polymorphismcalcification |
| spellingShingle | Benny Giovanni Cazarín-Santos Nonanzit Pérez-Hernández Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Óscar Pérez-Méndez Juan Rodríguez-Silverio Bladimir Roque-Ramírez Verónica Marusa Borgonio-Cuadra José Manuel Rodríguez-Pérez Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population Diagnostics osteoprotegerin subclinical atherosclerosis genetic susceptibility single nucleotide polymorphism calcification |
| title | Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population |
| title_full | Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population |
| title_fullStr | Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population |
| title_full_unstemmed | Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population |
| title_short | Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population |
| title_sort | osteoprotegerin gene polymorphisms are associated with subclinical atherosclerosis in the mexican mestizo population |
| topic | osteoprotegerin subclinical atherosclerosis genetic susceptibility single nucleotide polymorphism calcification |
| url | https://www.mdpi.com/2075-4418/12/6/1433 |
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