Gestational and postnatal age associations for striatal tissue iron deposition in early infancy
Striatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-invasive way to probe striatal physiology neonatally, linked t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000919 |
| _version_ | 1797671425303117824 |
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| author | Laura Cabral Finnegan J. Calabro Jerod Rasmussen Will Foran Lucille A. Moore Alice Graham Thomas G. O’Connor Pathik D. Wadhwa Sonja Entringer Damien Fair Claudia Buss Ashok Panigrahy Beatriz Luna |
| author_facet | Laura Cabral Finnegan J. Calabro Jerod Rasmussen Will Foran Lucille A. Moore Alice Graham Thomas G. O’Connor Pathik D. Wadhwa Sonja Entringer Damien Fair Claudia Buss Ashok Panigrahy Beatriz Luna |
| author_sort | Laura Cabral |
| collection | DOAJ |
| description | Striatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-invasive way to probe striatal physiology neonatally, linked to dopaminergic processing and cognition in children and adults. Striatal subregions have distinct functions that may come online at different time periods in early life. To identify if there are critical periods before or after birth, we measured if striatal iron accrued with gestational age at birth [range= 34.57–41.85 weeks] or postnatal age at scan [range= 5–64 days], using MRI to probe the T2* signal in N = 83 neonates in three striatal subregions. We found iron increased with postnatal age in the pallidum and putamen but not the caudate. No significant relationship between iron and gestational age was observed. Using a subset of infants scanned at preschool age (N = 26), we show distributions of iron shift between time points. In infants, the pallidum had the least iron of the three regions but had the most by preschool age. Together, this provides evidence of distinct change for striatal subregions, a possible differentiation between motor and cognitive systems, identifying a mechanism that may impact future trajectories. |
| first_indexed | 2024-03-11T21:15:21Z |
| format | Article |
| id | doaj.art-d19fb6f3bc53472cbe20820eeb2af363 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-11T21:15:21Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-d19fb6f3bc53472cbe20820eeb2af3632023-09-29T04:43:59ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-10-0163101286Gestational and postnatal age associations for striatal tissue iron deposition in early infancyLaura Cabral0Finnegan J. Calabro1Jerod Rasmussen2Will Foran3Lucille A. Moore4Alice Graham5Thomas G. O’Connor6Pathik D. Wadhwa7Sonja Entringer8Damien Fair9Claudia Buss10Ashok Panigrahy11Beatriz Luna12Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA; Corresponding author.Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USADevelopment, Health and Disease Research Program, University of California, Irvine, CA 92697, USA; Department of Pediatrics, University of California, Irvine, CA 92697, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USAMasonic Institute for the Developing Brain, University of Minnesota, USADepartment of Psychiatry, Oregon Health & Science University, Portland, OR 97239, USADepartments of Psychiatry, Neuroscience, and Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USADevelopment, Health, and Disease Research Program, Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange, CA, USA; Departments of Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Orange, CA, USADevelopment, Health, and Disease Research Program, Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange, CA, USA; Institute of Medical Psychology, Charité– Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt–Universität zu Berlin, Berlin, GermanyMasonic Institute for the Developing Brain, University of Minnesota, USADevelopment, Health, and Disease Research Program, Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange, CA, USA; Institute of Medical Psychology, Charité– Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt–Universität zu Berlin, Berlin, GermanyDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USAStriatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-invasive way to probe striatal physiology neonatally, linked to dopaminergic processing and cognition in children and adults. Striatal subregions have distinct functions that may come online at different time periods in early life. To identify if there are critical periods before or after birth, we measured if striatal iron accrued with gestational age at birth [range= 34.57–41.85 weeks] or postnatal age at scan [range= 5–64 days], using MRI to probe the T2* signal in N = 83 neonates in three striatal subregions. We found iron increased with postnatal age in the pallidum and putamen but not the caudate. No significant relationship between iron and gestational age was observed. Using a subset of infants scanned at preschool age (N = 26), we show distributions of iron shift between time points. In infants, the pallidum had the least iron of the three regions but had the most by preschool age. Together, this provides evidence of distinct change for striatal subregions, a possible differentiation between motor and cognitive systems, identifying a mechanism that may impact future trajectories.http://www.sciencedirect.com/science/article/pii/S1878929323000919Tissue ironStriatumSubcortical developmentEarly brain trajectoriesDevelopment of t2* signal in infancy |
| spellingShingle | Laura Cabral Finnegan J. Calabro Jerod Rasmussen Will Foran Lucille A. Moore Alice Graham Thomas G. O’Connor Pathik D. Wadhwa Sonja Entringer Damien Fair Claudia Buss Ashok Panigrahy Beatriz Luna Gestational and postnatal age associations for striatal tissue iron deposition in early infancy Developmental Cognitive Neuroscience Tissue iron Striatum Subcortical development Early brain trajectories Development of t2* signal in infancy |
| title | Gestational and postnatal age associations for striatal tissue iron deposition in early infancy |
| title_full | Gestational and postnatal age associations for striatal tissue iron deposition in early infancy |
| title_fullStr | Gestational and postnatal age associations for striatal tissue iron deposition in early infancy |
| title_full_unstemmed | Gestational and postnatal age associations for striatal tissue iron deposition in early infancy |
| title_short | Gestational and postnatal age associations for striatal tissue iron deposition in early infancy |
| title_sort | gestational and postnatal age associations for striatal tissue iron deposition in early infancy |
| topic | Tissue iron Striatum Subcortical development Early brain trajectories Development of t2* signal in infancy |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000919 |
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