Angiopoietin-2 is critical for cytokine-induced vascular leakage.

Angiopoietin-2 is critical for cytokine-induced vascular leakage.

Genetic experiments (loss-of-function and gain-of-function) have established the role of Angiopoietin/Tie ligand/receptor tyrosine kinase system as a regulator of vessel maturation and quiescence. Angiopoietin-2 (Ang-2) acts on Tie2-expressing resting endothelial cells as an antagonistic ligand to n...

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Bibliographic Details
Main Authors:	Andrew V Benest, Karoline Kruse, Soniya Savant, Markus Thomas, Anna M Laib, Elias K Loos, Ulrike Fiedler, Hellmut G Augustin
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3734283?pdf=render

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