Epidemiological and Clinical Characteristics of Kawasaki Disease in Mazandaran
Background and purpose: Kawasaki is an acute childhood vasculitis of unknown cause that if left untreated can cause coronary aneurysms in 25% of cases. The disease is reported as the leading cause of acquired heart disease in children in developed countries. The purpose of this study was to investig...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2022-09-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-18176-en.html |
| _version_ | 1797893178184957952 |
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| author | Mahboube Jafari Sarouei Mahsa Kamali Fahimeh Ghasemi Charati Leila Shahbaznejad Azin Hajalibeig Kiana Razavi-Amoli Mohammad Sadegh Rezai |
| author_facet | Mahboube Jafari Sarouei Mahsa Kamali Fahimeh Ghasemi Charati Leila Shahbaznejad Azin Hajalibeig Kiana Razavi-Amoli Mohammad Sadegh Rezai |
| author_sort | Mahboube Jafari Sarouei |
| collection | DOAJ |
| description | Background and purpose: Kawasaki is an acute childhood vasculitis of unknown cause that if left untreated can cause coronary aneurysms in 25% of cases. The disease is reported as the leading cause of acquired heart disease in children in developed countries. The purpose of this study was to investigate the epidemiological and clinical features of Kawasaki disease in northern Iran.
Materials and methods: In this descriptive-analytic review study, all registered cases of Kawasaki disease in Mazandaran province between 2007 and 2019 were investigated. Epidemiological, demographic, clinical, periodical tests, risk factors, disease burden, complications, and follow-up information were collected. Data analysis was done applying descriptive statistics, Chi-square test, and logistic regression.
Results: The data of 136 children with Kawasaki disease were assessed. Clinical symptoms were found to be significantly different between children with complete and incomplete Kawasaki disease (P<0.001). Most children with complete and incomplete Kawasaki disease had heart disease (63.2% and 75.5%, respectively), and coronary artery disease (52.6% and 58.2%, respectively) but no significant differences were found between the two groups in terms of cardiovascular involvement (P>0.05). Multivariate regression analysis showed that fever for more than 5 days is a predictor of coronary artery involvement (P= 0.001).
Conclusion: The study showed that fever for more than 5 days is a risk factor for heart and coronary artery involvement as one of the complications leading to death in these children. Therefore, accurate control of fever and heart examinations are important in children with symptoms of |
| first_indexed | 2024-04-10T06:49:55Z |
| format | Article |
| id | doaj.art-d1a18cab92ca4dcd931e6560fd85e964 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T06:49:55Z |
| publishDate | 2022-09-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-d1a18cab92ca4dcd931e6560fd85e9642023-02-28T09:08:23ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792022-09-013221297106Epidemiological and Clinical Characteristics of Kawasaki Disease in MazandaranMahboube Jafari Sarouei0Mahsa Kamali1Fahimeh Ghasemi Charati2Leila Shahbaznejad3Azin Hajalibeig4Kiana Razavi-Amoli5Mohammad Sadegh Rezai6 Assistant Professor, Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran MSc in Nursing, Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran MSc in Nursing, Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Pediatrician, Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Medical Student, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran Professor, Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Kawasaki is an acute childhood vasculitis of unknown cause that if left untreated can cause coronary aneurysms in 25% of cases. The disease is reported as the leading cause of acquired heart disease in children in developed countries. The purpose of this study was to investigate the epidemiological and clinical features of Kawasaki disease in northern Iran. Materials and methods: In this descriptive-analytic review study, all registered cases of Kawasaki disease in Mazandaran province between 2007 and 2019 were investigated. Epidemiological, demographic, clinical, periodical tests, risk factors, disease burden, complications, and follow-up information were collected. Data analysis was done applying descriptive statistics, Chi-square test, and logistic regression. Results: The data of 136 children with Kawasaki disease were assessed. Clinical symptoms were found to be significantly different between children with complete and incomplete Kawasaki disease (P<0.001). Most children with complete and incomplete Kawasaki disease had heart disease (63.2% and 75.5%, respectively), and coronary artery disease (52.6% and 58.2%, respectively) but no significant differences were found between the two groups in terms of cardiovascular involvement (P>0.05). Multivariate regression analysis showed that fever for more than 5 days is a predictor of coronary artery involvement (P= 0.001). Conclusion: The study showed that fever for more than 5 days is a risk factor for heart and coronary artery involvement as one of the complications leading to death in these children. Therefore, accurate control of fever and heart examinations are important in children with symptoms ofhttp://jmums.mazums.ac.ir/article-1-18176-en.htmlkawasaki diseasechildrenskin rashvasculitis |
| spellingShingle | Mahboube Jafari Sarouei Mahsa Kamali Fahimeh Ghasemi Charati Leila Shahbaznejad Azin Hajalibeig Kiana Razavi-Amoli Mohammad Sadegh Rezai Epidemiological and Clinical Characteristics of Kawasaki Disease in Mazandaran Journal of Mazandaran University of Medical Sciences kawasaki disease children skin rash vasculitis |
| title | Epidemiological and Clinical Characteristics of Kawasaki Disease in Mazandaran |
| title_full | Epidemiological and Clinical Characteristics of Kawasaki Disease in Mazandaran |
| title_fullStr | Epidemiological and Clinical Characteristics of Kawasaki Disease in Mazandaran |
| title_full_unstemmed | Epidemiological and Clinical Characteristics of Kawasaki Disease in Mazandaran |
| title_short | Epidemiological and Clinical Characteristics of Kawasaki Disease in Mazandaran |
| title_sort | epidemiological and clinical characteristics of kawasaki disease in mazandaran |
| topic | kawasaki disease children skin rash vasculitis |
| url | http://jmums.mazums.ac.ir/article-1-18176-en.html |
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