Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway

Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway

Abstract Background CDGSH iron sulfur domain 2 (CISD2) is an iron–sulfur protein with a [2Fe–2S] cluster, which is critical for cell proliferation and iron homeostasis. It has been demonstrated that aberrant expression of CISD2 is associated with the progression of multiple cancers. However, the und...

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Bibliographic Details
Main Authors: Yanchun Li, Bing Xu, Xueying Ren, Luyang Wang, Yaqing Xu, Yefeng Zhao, Chen Yang, Chen Yuan, Huanjuan Li, Xiangmin Tong, Ying Wang, Jing Du
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cellular & Molecular Biology Letters
Subjects:
CISD2
Iron
Autophagy
Ferroptosis
Ferritinophagy
Online Access:https://doi.org/10.1186/s11658-022-00383-z

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