Transcriptional Pattern Analysis of Virus-Specific CD8+ T Cells in Hepatitis C Infection: Increased Expression of TOX and Eomesodermin During and After Persistent Antigen Recognition

Transcriptional Pattern Analysis of Virus-Specific CD8+ T Cells in Hepatitis C Infection: Increased Expression of TOX and Eomesodermin During and After Persistent Antigen Recognition

Thymocyte selection-associated high mobility group box (TOX) has been described to be a key regulator in the formation of CD8+ T cell exhaustion. Hepatitis C virus (HCV) infection with different lengths of antigen exposure in acute, chronic, and after resolution of HCV infection is the ideal immunol...

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Bibliographic Details
Main Authors: Nils H. Wildner, Andreas Walker, Franziska Brauneck, Vanessa Ditt, Sven Peine, Samuel Huber, Friedrich Haag, Claudia Beisel, Joerg Timm, Julian Schulze zur Wiesch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
chronic viral hepatitis
hepatitis C
acute viral hepatitis
T cell differentiation
T cell exhaustion
TOX
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.886646/full

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