Topical Sustained Delivery of Miltefosine Via Drug-Eluting Contact Lenses to Treat Acanthamoeba Keratitis

Topical Sustained Delivery of Miltefosine Via Drug-Eluting Contact Lenses to Treat Acanthamoeba Keratitis

This study aimed to develop a miltefosine-eluting contact lens (MLF-CL) device that would allow sustained and localized miltefosine release for the treatment of Acanthamoeba keratitis. MLF-CLs were produced in three different miltefosine doses by solvent-casting a thin miltefosine-polymer film aroun...

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Bibliographic Details
Main Authors: Lin Chen, Liangju Kuang, Amy E. Ross, Wissam Farhat, Nikolay Boychev, Sina Sharfi, Levi N. Kanu, Longqian Liu, Daniel S. Kohane, Joseph B. Ciolino
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
acanthamoeba keratitis
controlled drug delivery
contact lens
miltefosine
PLGA
Online Access:https://www.mdpi.com/1999-4923/14/12/2750

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